The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases

被引：23

作者：

Liu, Wei ^{[1
]}

Shi, Lian-jie ^{[2
]}

Li, Sheng-guang ^{[2
]}

机构：

[1] Fujian Med Univ, Dept Resp & Crit Care Med, PLA, Hosp 900,Joint Logist Support Force, Fuzhou 350025, Fujian, Peoples R China

[2] Peking Univ, Dept Rheumatol & Immunol, Int Hosp, Beijing 102206, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2019年 / 2019卷

关键词：

ACTIVATED PROTEIN-KINASE; IKK-BETA SUPPRESSION; OXIDATIVE STRESS; CORTICAL-NEURONS; STIMULATION; EXPRESSION; INDUCTION; SECRETION; LINKS;

D O I：

10.1155/2019/8086257

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

lpha-lipoic acid is a naturally occurring antioxidant in human body and has been widely used as an antioxidant clinically. Accumulating evidences suggested that -lipoic acid might have immunomodulatory effects on both adaptive and innate immune systems. This review focuses on the evidences and potential targets involved in the immunomodulatory effects of -lipoic acid. It highlights the fact that -lipoic acid may have beneficial effects in autoimmune diseases once the immunomodulatory effects can be confirmed by further investigation.

引用

页数：11

共 121 条

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