Comparative Evaluation of Antiproliferative Effects of Brazilian Green Propolis, Its Main Source Baccharis dracunculifolia, and Their Major Constituents Artepillin C and Baccharin

被引：23

作者：

de Oliveira, Pollyanna Francielli ^{[1
]}

de Souza Lima, Ildercilio Mota ^{[1
]}

Munari, Carla Carolina ^{[1
]}

Bastos, Jairo Kenupp ^{[2
]}

da Silva Filho, Ademar Alves ^{[3
]}

Tavares, Denise Crispim ^{[1
]}

机构：

[1] Univ Franca, BR-14404600 Sao Paulo, Brazil

[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo, Brazil

[3] Univ Fed Juiz de Fora, Fac Farm, Dept Ciencias Farmaceut, Juiz De Fora, MG, Brazil

来源：

PLANTA MEDICA | 2014年 / 80卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

baccharin; artepillin C; Baccharis dracunculifolia; green propolis; Asteraceae; CINNAMIC ACID-DERIVATIVES; EXTRACT; CELLS; INHIBITION;

D O I：

10.1055/s-0034-1368298

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

This study evaluated the antiproliferative activity of the Brazilian green propolis and Baccharis dracunculifolia extracts and their major compounds artepillin C and baccharin in different tumor cell lines. The lowest IC50 values observed for Brazilian green propolis and B. dracunculifolia extracts were 41.0 +/- 4.5 mu g/mL for U343 and 44.9 +/- 7.1 mu g/mL for HepG2, respectively. Regarding artepillin C and baccharin, the lowest IC50 values were 20.1 +/- 2.9 for U343 and 13.0 +/- 1.5 mu g/mL for B16F10, respectively. For the association of artepillin C plus baccharin, the lowest IC50 result was 35.2 +/- 0.5 mu g/mL for B16F10. Artepillin C and baccharin were more cytotoxic than both Brazilian green propolis and B. dracunculifolia extracts. No additive or synergistic effect was observed for the association of artepillin C plus baccharin.

引用

页码：490 / 492

页数：3

共 13 条

[11] Antigenotoxicity and antimutagenicity of ethanolic extracts of Brazilian green propolis and its main botanical source determined by the Allium cepa test system
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Jamal, Claudia Masrouah
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[12] Brazilian Green Propolis' Artepillin C and Its Acetylated Derivative Activate the NGF-Signaling Pathways and Induce Neurite Outgrowth in NGF-Deprived PC12 Cells
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Parreira, Renato Luis Tame
dos Santos, Antonio Cardozo
Bastos, Jairo Kenupp
CHEMISTRY & BIODIVERSITY, 2023, 20 (12)
[13] Enhanced production of IL-2 from anti-CD3 antibody-stimulated mouse spleen cells by artepillin C, a major component of Brazilian green propolis
Tsuruta, Hanemi
Mizuno-Kamiya, Masako
Takahashi, Moe
Ando, Megumi
Ikeno, Kumiko
Ueno, Kyohei
Takayama, Eiji
Kawaki, Harumi
Nakamura, Genjiro
Nikaido, Toru
Fujita, Hisakazu
Kondoh, Nobuo
JOURNAL OF ORAL BIOSCIENCES, 2022, 64 (03) : 366 - 375

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