Comparative Evaluation of Antiproliferative Effects of Brazilian Green Propolis, Its Main Source Baccharis dracunculifolia, and Their Major Constituents Artepillin C and Baccharin

被引：23
|
作者：
de Oliveira, Pollyanna Francielli [1 ]
de Souza Lima, Ildercilio Mota [1 ]
Munari, Carla Carolina [1 ]
Bastos, Jairo Kenupp [2 ]
da Silva Filho, Ademar Alves [3 ]
Tavares, Denise Crispim [1 ]
机构：
[1] Univ Franca, BR-14404600 Sao Paulo, Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo, Brazil
[3] Univ Fed Juiz de Fora, Fac Farm, Dept Ciencias Farmaceut, Juiz De Fora, MG, Brazil
来源：
PLANTA MEDICA | 2014年 / 80卷 / 06期
基金：
巴西圣保罗研究基金会;
关键词：
baccharin; artepillin C; Baccharis dracunculifolia; green propolis; Asteraceae; CINNAMIC ACID-DERIVATIVES; EXTRACT; CELLS; INHIBITION;
D O I：
10.1055/s-0034-1368298
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
This study evaluated the antiproliferative activity of the Brazilian green propolis and Baccharis dracunculifolia extracts and their major compounds artepillin C and baccharin in different tumor cell lines. The lowest IC50 values observed for Brazilian green propolis and B. dracunculifolia extracts were 41.0 +/- 4.5 mu g/mL for U343 and 44.9 +/- 7.1 mu g/mL for HepG2, respectively. Regarding artepillin C and baccharin, the lowest IC50 values were 20.1 +/- 2.9 for U343 and 13.0 +/- 1.5 mu g/mL for B16F10, respectively. For the association of artepillin C plus baccharin, the lowest IC50 result was 35.2 +/- 0.5 mu g/mL for B16F10. Artepillin C and baccharin were more cytotoxic than both Brazilian green propolis and B. dracunculifolia extracts. No additive or synergistic effect was observed for the association of artepillin C plus baccharin.
引用
收藏
页码：490 / 492
页数：3
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