Atherosclerosis as autoimmune disease

被引：48
作者：
Sima, Petr [1 ]
Vannucci, Luca [1 ]
Vetvicka, Vaclav [2 ]
机构：
[1] Inst Microbiol, Lab Immunotherapy, Prague, Czech Republic
[2] Univ Louisville, Dept Pathol, Louisville, KY 40202 USA
来源：
ANNALS OF TRANSLATIONAL MEDICINE | 2018年 / 6卷 / 07期
关键词：
Atherosclerosis; cholesterol; immunity; inflammation; LOW-DENSITY-LIPOPROTEIN; SMOOTH-MUSCLE-CELLS; CAROTID ATHEROSCLEROSIS; IMMUNE-MECHANISMS; DENDRITIC CELLS; T-LYMPHOCYTES; OXIDIZED LDL; EXPRESSION; MACROPHAGE; RESPONSES;
D O I：
10.21037/atm.2018.02.02
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
No attention is usually focused on the possible involvement of immune mechanisms, particularly of autoimmunity, on the development and progress of atherosclerosis. The pioneering work occurring almost 50 years ago was overlooked, and the idea of atherosclerosis as an autoimmune disease only started gaining traction about 10 years ago. Our review discusses the recent findings and offers insights into the possibility that alterations of the immune system play a significant role in the development of atherosclerosis.
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页数：6
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