Mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis

被引：45

作者：

Qu, Kai ^{[1
,2
]}

Yan, Fang ^{[3
,4
]}

Qin, Xian ^{[1
,2
]}

Zhang, Kun ^{[1
,2
]}

He, Wen ^{[5
]}

Dong, Mingqing ^{[4
]}

Wu, Guicheng ^{[1
]}

机构：

[1] Chongqing Univ, Clin Res Ctr Endocrinol & Metab Dis, Three Gorges Hosp, Chongqing, Peoples R China

[2] Chongqing Univ, Coll Bioengn, Chongqing, Peoples R China

[3] Chengdu Fifth Peoples Hosp, Geriatr Dis Inst Chengdu, Dept Geriatr, Chengdu, Sichuan, Peoples R China

[4] Chengdu Fifth Peoples Hosp, Ctr Med Res & Translat, Chengdu, Sichuan, Peoples R China

[5] Chengdu Fifth Peoples Hosp, Clin Trial Ctr, Dept Geriatr, Chengdu, Sichuan, Peoples R China

来源：

FRONTIERS IN PHYSIOLOGY | 2022年 / 13卷

关键词：

mitochondrial dysfunction; endothelial cells; atherosclerosis; mitochondrial ROS; mitophagy; NLRP3 INFLAMMASOME ACTIVATION; INDUCED OXIDATIVE STRESS; MESENCHYMAL TRANSITION; ENDOPLASMIC-RETICULUM; MOLECULAR-MECHANISMS; PLAQUE PROGRESSION; INDUCED MITOPHAGY; NITRIC-OXIDE; DNA DAMAGE; COMPLEX I;

D O I：

10.3389/fphys.2022.1084604

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The mitochondria are essential organelles that generate large amounts of ATP via the electron transport chain (ECT). Mitochondrial dysfunction causes reactive oxygen species accumulation, energy stress, and cell death. Endothelial mitochondrial dysfunction is an important factor causing abnormal function of the endothelium, which plays a central role during atherosclerosis development. Atherosclerosis-related risk factors, including high glucose levels, hypertension, ischemia, hypoxia, and diabetes, promote mitochondrial dysfunction in endothelial cells. This review summarizes the physiological and pathophysiological roles of endothelial mitochondria in endothelial function and atherosclerosis.

引用

页数：20

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