Mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis

被引：45
|
作者：
Qu, Kai [1 ,2 ]
Yan, Fang [3 ,4 ]
Qin, Xian [1 ,2 ]
Zhang, Kun [1 ,2 ]
He, Wen [5 ]
Dong, Mingqing [4 ]
Wu, Guicheng [1 ]
机构：
[1] Chongqing Univ, Clin Res Ctr Endocrinol & Metab Dis, Three Gorges Hosp, Chongqing, Peoples R China
[2] Chongqing Univ, Coll Bioengn, Chongqing, Peoples R China
[3] Chengdu Fifth Peoples Hosp, Geriatr Dis Inst Chengdu, Dept Geriatr, Chengdu, Sichuan, Peoples R China
[4] Chengdu Fifth Peoples Hosp, Ctr Med Res & Translat, Chengdu, Sichuan, Peoples R China
[5] Chengdu Fifth Peoples Hosp, Clin Trial Ctr, Dept Geriatr, Chengdu, Sichuan, Peoples R China
来源：
FRONTIERS IN PHYSIOLOGY | 2022年 / 13卷
关键词：
mitochondrial dysfunction; endothelial cells; atherosclerosis; mitochondrial ROS; mitophagy; NLRP3 INFLAMMASOME ACTIVATION; INDUCED OXIDATIVE STRESS; MESENCHYMAL TRANSITION; ENDOPLASMIC-RETICULUM; MOLECULAR-MECHANISMS; PLAQUE PROGRESSION; INDUCED MITOPHAGY; NITRIC-OXIDE; DNA DAMAGE; COMPLEX I;
D O I：
10.3389/fphys.2022.1084604
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The mitochondria are essential organelles that generate large amounts of ATP via the electron transport chain (ECT). Mitochondrial dysfunction causes reactive oxygen species accumulation, energy stress, and cell death. Endothelial mitochondrial dysfunction is an important factor causing abnormal function of the endothelium, which plays a central role during atherosclerosis development. Atherosclerosis-related risk factors, including high glucose levels, hypertension, ischemia, hypoxia, and diabetes, promote mitochondrial dysfunction in endothelial cells. This review summarizes the physiological and pathophysiological roles of endothelial mitochondria in endothelial function and atherosclerosis.
引用
收藏
页数：20
相关论文
共 50 条
  • [21] Role of Endothelial Cell-Derived Angptl2 in Vascular Inflammation Leading to Endothelial Dysfunction and Atherosclerosis Progression
    Horio, Eiji
    Kadomatsu, Tsuyoshi
    Miyata, Keishi
    Arai, Yasumichi
    Hosokawa, Kentaro
    Doi, Yasufumi
    Ninomiya, Toshiharu
    Horiguchi, Haruki
    Endo, Motoyoshi
    Tabata, Mitsuhisa
    Tazume, Hirokazu
    Tian, Zhe
    Takahashi, Otowa
    Terada, Kazutoyo
    Takeya, Motohiro
    Hao, Hiroyuki
    Hirose, Nobuyoshi
    Minami, Takashi
    Suda, Toshio
    Kiyohara, Yutaka
    Ogawa, Hisao
    Kaikita, Koichi
    Oike, Yuichi
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2014, 34 (04) : 790 - 800
  • [22] WHAT IS ENDOTHELIAL CELLS ROLE IN ATHEROSCLEROSIS
    不详
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1974, 230 (02): : 192 - 192
  • [23] ROLE OF ENDOTHELIAL CELLS IN PATHOGENESIS OF ATHEROSCLEROSIS
    IWANAGA, Y
    TANIMURA, A
    KITSUKAWA, H
    TANIGAWA, J
    AIHARA, M
    KAWASHIMA, T
    MAE, A
    NAKASHIMA, T
    ACTA PATHOLOGICA JAPONICA, 1969, 19 (02): : 161 - +
  • [24] Effects of mitochondrial dysfunction on cellular function: Role in atherosclerosis
    Xu, Minwen
    Wang, Wenjun
    Cheng, Jingpei
    Qu, Hongen
    Xu, Minjuan
    Wang, Liefeng
    BIOMEDICINE & PHARMACOTHERAPY, 2024, 174
  • [25] THE ROLE OF NITRIC OXIDE (NO) AND STATINS IN ENDOTHELIAL DYSFUNCTION AND ATHEROSCLEROSIS
    Suciu, Maria
    FARMACIA, 2009, 57 (02) : 131 - 140
  • [26] Dual role of lipoproteins in endothelial cell dysfunction in atherosclerosis
    Camelia S. Stancu
    Laura Toma
    Anca V. Sima
    Cell and Tissue Research, 2012, 349 : 433 - 446
  • [27] Dual role of lipoproteins in endothelial cell dysfunction in atherosclerosis
    Stancu, Camelia S.
    Toma, Laura
    Sima, Anca V.
    CELL AND TISSUE RESEARCH, 2012, 349 (02) : 433 - 446
  • [28] Endothelial cell senescence in human atherosclerosis - Role of telomere in endothelial dysfunction
    Minamino, T
    Miyauchi, H
    Yoshida, T
    Ishida, Y
    Yoshida, H
    Komuro, I
    CIRCULATION, 2002, 105 (13) : 1541 - 1544
  • [29] Mitochondrial Dynamics and Motility Inside Living Vascular Endothelial Cells: Role of Bioenergetics
    Giedt, Randy J.
    Pfeiffer, Douglas R.
    Matzavinos, Anastasios
    Kao, Chiu-Yen
    Alevriadou, B. Rita
    ANNALS OF BIOMEDICAL ENGINEERING, 2012, 40 (09) : 1903 - 1916
  • [30] Mitochondrial dysfunction in atherosclerosis
    Madamanchi, Nageswara R.
    Runge, Marschall S.
    CIRCULATION RESEARCH, 2007, 100 (04) : 460 - 473
12345