Regioselective synthesis of 9,10-dihydro-6H-chromeno[4,3-d]imidazo-[1,2-a]pyridin-6-one derivatives

被引：22

作者：

Yu, Fu-Chao ^{[1
,2
]}

Chen, Zhi-Qiong ^{[1
]}

Hao, Xiao-Pan ^{[1
]}

Yan, Sheng-Jiao ^{[1
]}

Huang, Rong ^{[3
]}

Lin, Jun ^{[1
,3
]}

机构：

[1] Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China

[2] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650504, Peoples R China

[3] Yunnan Univ, Adv Anal & Measurement Ctr, Kunming 650091, Peoples R China

来源：

RSC ADVANCES | 2014年 / 4卷 / 12期

基金：

中国国家自然科学基金;

关键词：

HETEROCYCLIC KETENE AMINALS; PHOSPHONYL IMINE CHEMISTRY; SOLVENT-FREE SYNTHESIS; COUMARIN DERIVATIVES; EFFICIENT SYNTHESIS; CASCADE REACTION; CHROMATOGRAPHY; DESIGN; ROUTE;

D O I：

10.1039/c3ra46428h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method for regioselective synthesis of 9,10-dihydro-6H-chromeno[4,3-d]imidazo[1,2-a]pyridin-6-one derivatives has been developed. The reaction was readily performed by reacting inexpensive materials, 4-chloro-3-formylcoumarin and HKAs, in EtOH catalyzed by Et3N. This protocol has many advantages including convenient operation, short reaction times, green solvent, and simple purification by washing the crude products with 95% EtOH, defined as GAP (Group-Assistant-Purification) chemistry. The library of 9,10-dihydro-6H-chromeno[4,3-d]imidazo[1,2-a]pyridin-6-one derivatives has been constructed with excellent yields.

引用

页码：6110 / 6115

页数：6

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