The Effect of Anesthesia on the Immune System in Colorectal Cancer Patients

被引：36
作者：
Dang, Yangjie [1 ]
Shi, Xingxing [1 ]
Xu, William [2 ]
Zuo, Mingzhang [3 ]
机构：
[1] Xian Childrens Hosp, Dept Anesthesiol, Xian 710032, Shaanxi, Peoples R China
[2] Univ Iowa, Dept Anesthesiol, Carver Coll Med, Iowa City, IA 52246 USA
[3] Beijing Hosp, Dept Anesthesiol, Natl Ctr Gerontol, 1 Dahua Rd, Beijing 100730, Peoples R China
来源：
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2018年 / 2018卷
基金：
中国国家自然科学基金;
关键词：
PERIOPERATIVE BLOOD-TRANSFUSION; TUMOR-ASSOCIATED MACROPHAGES; KILLER-CELL CYTOTOXICITY; CLASS-I; CARCINOEMBRYONIC ANTIGEN; REGIONAL ANESTHESIA; CURATIVE RESECTION; TERM SURVIVAL; T-CELLS; SURGERY;
D O I：
10.1155/2018/7940603
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Colorectal cancer (CRC) is the key leading cause of high morbidity and mortality worldwide. Surgical excision is the most effective treatment for CRC. However, stress caused by surgery response can destroy the body's immunity and increase the likelihood of cancer dissemination and metastasis. Anesthesia is an effective way to control the stress response, and recent basic and clinical research has shown that anesthesia and related drugs can directly or indirectly affect the immune system of colorectal cancer patients during the perioperative period. Thus, these drugs may affect the prognosis of CRC surgery patients. This review is intended to summarize currently available data regarding the effects of anesthetics and related drugs on perioperative immune function and postoperative recurrence and metastasis in CRC patients. Determining the most suitable anesthesia for patients with CRC is of utmost importance.
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页数：8
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