AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain

被引：46

作者：

Hosohata, K

Quock, RM

Hosohata, Y

Burkey, TH

Makriyannis, A

Consroe, P

Roeske, WR

Yamamura, HI

机构：

[1] UNIV ARIZONA, HLTH SCI CTR, COLL MED, DEPT PHARMACOL, TUCSON, AZ 85724 USA

[2] UNIV ARIZONA, HLTH SCI CTR, DEPT PHARMACOL & TOXICOL, TUCSON, AZ 85724 USA

[3] UNIV ARIZONA, HLTH SCI CTR, DEPT BIOCHEM, TUCSON, AZ 85724 USA

[4] UNIV ARIZONA, HLTH SCI CTR, DEPT PSYCHIAT, TUCSON, AZ 85724 USA

[5] UNIV ARIZONA, HLTH SCI CTR, PROGRAM NEUROSCI, TUCSON, AZ 85724 USA

[6] UNIV CONNECTICUT, SCH PHARM, STORRS, CT 06269 USA

[7] UNIV ILLINOIS, COLL MED, DEPT BIOMED SCI, ROCKFORD, IL 61107 USA

来源：

LIFE SCIENCES | 1997年 / 61卷 / 09期

关键词：

cannabinoid antagonist; S-35]GTP gamma S binding; guinea pig;

D O I：

10.1016/S0024-3205(97)00596-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

AM630 has been demonstrated to be a cannabinoid receptor antagonist in the mouse brain and vas deferens. Conversely, it was recently reported that AM630 acts as a cannabinoid agonist in the guinea pig ileum. This research was designed to determine whether the difference in the action of AM630 is species specific. Studies conducted in guinea pig brain reveal that AM630 antagonizes the stimulatory effect of the cannabinoid agonist WIN 55,212-2 on [S-35]GTP gamma S binding suggesting that difference in AM630 activity in different tissues is not due to species (C) 1997 Elsevier Science Inc.

引用

页码：PL115 / PL118

页数：4

共 8 条

[1] HOSOHATA Y, IN PRESS EUR J PHARM
[2] AM630, A COMPETITIVE CANNABINOID RECEPTOR ANTAGONIST
PERTWEE, R
GRIFFIN, G
FERNANDO, S
LI, XY
HILL, A
MAKRIYANNIS, A
[J]. LIFE SCIENCES, 1995, 56 (23-24) : 1949 - 1955
[3] Further evidence for the presence of cannabinoid CBI receptors in guinea-pig small intestine
Pertwee, RG
Fernando, SR
Nash, JE
Coutts, AA
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1996, 118 (08) : 2199 - 2205
[4] SR141716A, A POTENT AND SELECTIVE ANTAGONIST OF THE BRAIN CANNABINOID RECEPTOR
RINALDICARMONA, M
BARTH, F
HEAULME, M
SHIRE, D
CALANDRA, B
CONGY, C
MARTINEZ, S
MARUANI, J
NELIAT, G
CAPUT, D
FERRARA, P
SOUBRIE, P
BRELIERE, JC
LEFUR, G
[J]. FEBS LETTERS, 1994, 350 (2-3): : 240 - 244
[5] Cannabinoid receptor stimulation of guanosine-5'-O-(3-[S-35]thio)triphosphate binding in rat brain membranes
Selley, DE
Stark, S
Sim, LJ
Childers, SR
[J]. LIFE SCIENCES, 1996, 59 (08) : 659 - 668
[6] Tallarida R. J., 1987, MANUAL PHARM CALCULA, P53
[7] PHARMACOLOGICAL PROFILES OF BETA-FUNALTREXAMINE (BETA-FNA) AND BETA-CHLORNALTREXAMINE (BETA-CNA) ON THE MOUSE VAS-DEFERENS PREPARATION
WARD, SJ
PORTOGHESE, PS
TAKEMORI, AE
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1982, 80 (04) : 377 - 384
[8] WARD SJ, 1982, J PHARMACOL EXP THER, V220, P494

← 1 →