Topical Timolol 0.5% Gel-Forming Solution for Small Deep Facial Infantile Hemangiomas

被引:11
作者
Sorrell, Jennifer [1 ]
Chamlin, Sarah L. [2 ]
机构
[1] Northwestern Univ, Dept Dermatol, Feinberg Sch Med, Chicago, IL 60611 USA
[2] Ann & Robert H Lurie Childrens Hosp Chicago, Div Pediat Dermatol, Feinberg Sch Med, Chicago, IL 60611 USA
关键词
MALEATE;
D O I
10.1111/pde.12209
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
We report three cases of successful treatment of proliferating deep infantile hemangiomas with topical timolol 0.5% gel-forming solution (GFS) used two to three times daily. We recommend considering timolol as an initial option for small, deep facial hemangiomas that are not causing functional compromise or complications but may have an unsatisfactory cosmetic appearance. In our experience, albeit limited, this is a safe alternative to watchful waiting.
引用
收藏
页码:592 / 594
页数:3
相关论文
共 10 条
[1]   Timolol Maleate 0.5% or 0.1% Gel-Forming Solution for Infantile Hemangiomas: A Retrospective, Multicenter, Cohort Study [J].
Chakkittakandiyil, Ajith ;
Phillips, Rod ;
Frieden, Ilona J. ;
Siegfried, Elaine ;
Lara-Corrales, Irene ;
Lam, Joseph ;
Bergmann, James ;
Bekhor, Philip ;
Poorsattar, Solmaz ;
Pope, Elena .
PEDIATRIC DERMATOLOGY, 2012, 29 (01) :28-31
[2]   A Controlled Study of Topical 0.25% Timolol Maleate Gel for the Treatment of Cutaneous Infantile Capillary Hemangiomas [J].
Chambers, Christopher B. ;
Katowitz, William R. ;
Katowitz, James A. ;
Binenbaum, Gil .
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY, 2012, 28 (02) :103-106
[3]   Propranolol concentrations after oral administration in term and preterm neonates [J].
Filippi, L. ;
Cavallaro, G. ;
Fiorini, P. ;
Malvagia, S. ;
Della Bona, M. L. ;
Giocaliere, E. ;
Bagnoli, P. ;
Dal Monte, M. ;
Mosca, F. ;
Donzelli, G. ;
la Marca, G. .
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2013, 26 (08) :833-840
[4]   Systemic bioavailability and cardiopulmonary effects of 0.5% timolol eyedrops [J].
Korte, JM ;
Kaila, T ;
Saari, KM .
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2002, 240 (06) :430-435
[5]   Topical Timolol for Infantile Hemangiomas: Putting a Note of Caution in "Cautiously Optimistic" [J].
McMahon, Patrick ;
Oza, Vikash ;
Frieden, Ilona J. .
PEDIATRIC DERMATOLOGY, 2012, 29 (01) :127-130
[6]   Ophthalmic timolol:: Plasma concentration and systemic cardiopulmonary effects [J].
Nieminen, T. ;
Lehtimaki, T. ;
Maenpaa, J. ;
Ropo, A. ;
Uusitalo, H. ;
Kahonen, M. .
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2007, 67 (02) :237-245
[7]   Treatment of Small Superficial Haemangioma with Timolol 0.5% Ophthalmic Solution: A Series of 20 Cases [J].
Oranje, A. P. ;
Janmohamed, S. R. ;
Madern, G. C. ;
de laat, P. C. J. .
DERMATOLOGY, 2011, 223 (04) :330-334
[8]  
Pope E, 2010, ARCH DERMATOL, V146, P564, DOI 10.1001/archdermatol.2010.67
[9]   Topical timolol maleate for treatment of infantile haemangiomas: preliminary results of a prospective study [J].
Semkova, K. ;
Kazandjieva, J. .
CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2013, 38 (02) :143-146
[10]   Efficacy and systemic side-effects of topical 0.5% timolol aqueous solution and 0.1% timolol hydrogel [J].
Uusitalo, H ;
Niño, J ;
Tahvanainen, K ;
Turjanmaa, V ;
Ropo, A ;
Tuominen, J ;
Kähönen, M .
ACTA OPHTHALMOLOGICA SCANDINAVICA, 2005, 83 (06) :723-728