Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases

被引：91
作者：
Chen, Ruochan [1 ,2 ,3 ]
Hou, Wen [1 ]
Zhang, Qiuhong [1 ]
Kang, Rui [1 ]
Fan, Xue-Gong [2 ,3 ]
Tang, Daolin [1 ]
机构：
[1] Univ Pittsburgh, Dept Surg, Pittsburgh, PA USA
[2] Cent South Univ, Xiangya Hosp, Dept Infect Dis, Changsha, Hunan, Peoples R China
[3] Cent South Univ, Xiangya Hosp, State Key Lab Viral Hepatitis, Changsha, Hunan, Peoples R China
来源：
MOLECULAR MEDICINE | 2013年 / 19卷
基金：
美国国家卫生研究院;
关键词：
ISCHEMIA-REPERFUSION INJURY; HEPATIC ISCHEMIA/REPERFUSION INJURY; CHROMATIN PROTEIN HMGB1; END-PRODUCTS RAGE; RECEPTOR; HEPATOCELLULAR-CARCINOMA; LETHAL SEPSIS; CLINICOPATHOLOGICAL FEATURES; STERILE INFLAMMATION; THERAPEUTIC TARGET;
D O I：
10.2119/molmed.2013.00099
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Damage-associated molecular pattern (DAMP) molecules are essential for the initiation of innate inflammatory responses to infection and injury. The prototypic DAMP molecule, high-mobility group box 1 (HMGB1), is an abundant architectural chromosomal protein that has location-specific biological functions: within the nucleus as a DNA chaperone, within the cytosol to sustain autophagy and outside the cell as a DAMP molecule. Recent research indicates that aberrant activation of HMGB1 signaling can promote the onset of inflammatory and autoimmune diseases, raising interest in the development of therapeutic strategies to control their function. The importance of HMGB1 activation in various forms of liver disease in relation to liver damage, steatosis, inflammation, fibrosis, tumorigenesis and regeneration is discussed in this review.
引用
收藏
页码：357 / 366
页数：10
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