Palladium-catalyzed fluorination of carbon-hydrogen bonds

被引：511

作者：

Hull, Kami L. ^{[1
]}

Anani, Waseem Q. ^{[1
]}

Sanford, Melanie S. ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 22期

关键词：

D O I：

10.1021/ja061943k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This communication describes the development of a new Pd-catalyzed method for the fluorination of carbon-hydrogen bonds. A key step of these transformations involves palladium-mediated carbon-fluorine couplinga much sought after, but previously unprecedented, transformation. These reactions were successfully achieved under oxidative conditions using electrophilic N-fluoropyridinium reagents. Microwave irradiation in the presence of catalytic palladium acetate served as optimal conditions for the fluorination of C-H bonds in a variety of substituted 2-arylpyridine and 8-methylquinoline derivatives. Copyright © 2006 American Chemical Society.

引用

页码：7134 / 7135

页数：2

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