Tetrazoles for biomedicine

被引：93
作者：
Popova, Elena A. [1 ]
Trifonov, Rostislav E. [1 ,2 ]
Ostrovskii, Vladimir A. [2 ]
机构：
[1] St Petersburg State Univ, Dept Nat Cpds Chem, SPbU, Univ Skaya Nab 7-9, St Petersburg 199034, Russia
[2] Tech Univ, St Petersburg State Inst Technol, Moskovsky Prosp 26, St Petersburg 190013, Russia
来源：
RUSSIAN CHEMICAL REVIEWS | 2019年 / 88卷 / 06期
基金：
俄罗斯科学基金会;
关键词：
DINUCLEAR PLATINUM(II) COMPLEXES; NMDA AGONIST (TETRAZOL-5-YL)GLYCINE; FEATURING TETRAZOLYLACETIC ACIDS; COMBRETASTATIN A-4 ANALOGS; AMPA RECEPTOR ANTAGONISTS; IN-VITRO ANTIBACTERIAL; II TYPE-1 RECEPTOR; BIOLOGICAL EVALUATION; ANTIMICROBIAL ACTIVITY; MOLECULAR DOCKING;
D O I：
10.1070/RCR4864
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The tetrazole ring is an important pharmacophore. It is a structural component in many drugs, drug candidates (or lead compounds) and various biochemical reagents. This review summarizes data on the use of tetrazoles in biomedicine published in the last 10 - 15 years and also views on the nature of their biological effects. The prospects for the development of new biologically active substances containing a tetrazolyl pharmacophore are analyzed.
引用
收藏
页码：644 / 676
页数：33
相关论文
共 263 条
  • [1] Synthesis and Antimicrobial Activity of New Tetrazoles Incorporating Isoindole-1,3-dione Moiety and Their Sugar Derivatives
    Abdel-Rahman, Adel A. -H.
    Ali, Omar M.
    Abdel-Megeed, Amira A. -S.
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2013, 50 (03) : 484 - 489
  • [2] Unexpected formation of 1-[4-chloromethylphenyl]-5-[4-(methylsulfonyl)benzyl]-1H-tetrazole and 1-[4-chloromethylphenyl]-5[4-(aminosulfonyl)phenyl]-1H-tetrazole: Crystal structure, bioassay screening and molecular docking studies
    Al-Hourani, Baker Jawabrah
    Ali, Basem F.
    Judeh, Zaher
    El-Barghouthi, Musa I.
    Al-Awaida, Wajdy
    Snobar, Yasmin
    El Soubani, Fatima
    Matalka, Khalid
    Wuest, Frank
    [J]. JOURNAL OF MOLECULAR STRUCTURE, 2018, 1164 : 317 - 327
  • [3] Structure-activity relationship of novel series of 1,5-disubstituted tetrazoles as cyclooxygenase-2 inhibitors: Design, synthesis, bioassay screening and molecular docking studies
    Al-Hourani, Baker Jawabrah
    Al-Awaida, Wajdy
    Matalka, Khalid Z.
    El-Barghouthi, Musa I.
    Alsoubani, Fatima
    Wuest, Frank
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (19) : 4757 - 4762
  • [4] Synthesis and crystal structure of N-[(dimethylamino)methylidene]-4-[1-(4-nitropheny1)-1H-tetrazol-5-yl]-benzenesulfonamide: Molecular docking and bioassay studies as cyclooxygenase-2 inhibitor
    Al-Hourani, Baker Jawabrah
    El-Barghouthi, Musa I.
    McDonald, Robert
    Al-Awaida, Wajdy
    Sharma, Sai Kiran
    Wuest, Frank
    [J]. JOURNAL OF MOLECULAR STRUCTURE, 2016, 1119 : 220 - 226
  • [5] Docking studies and the crystal structure of two tetrazole derivatives: 5-(4-chlorophenyl)-1-{4-(methylsulfonyl)phenyl)-1H-tetrazole and 4-{5-(4-methoxyphenyl)-1H-tetrazol-1-yl}benzenesulfonamide
    Al-Hourani, Baker Jawabrah
    El-Barghouthi, Musa I.
    Mcdonald, Robert
    Al-Awaida, Wajdy
    Wuest, Frank
    [J]. JOURNAL OF MOLECULAR STRUCTURE, 2015, 1101 : 21 - 27
  • [6] Synthesis, bioassay studies, and molecular docking of novel 5-substituted 1H tetrazoles as cyclooxygenase-2 (COX-2) inhibitors
    Al-Hourani, Baker Jawabrah
    Sharma, Sai Kiran
    Kaur, Jatinder
    Wuest, Frank
    [J]. MEDICINAL CHEMISTRY RESEARCH, 2015, 24 (01) : 78 - 85
  • [7] Synthesis and evaluation of 1,5-diaryl-substituted tetrazoles as novel selective cyclooxygenase-2 (COX-2) inhibitors
    Al-Hourani, Baker Jawabrah
    Sharma, Sai Kiran
    Mane, Jonathan Y.
    Tuszynski, Jack
    Baracos, Vickie
    Kniess, Torsten
    Suresh, Mavanur
    Pietzsch, Jens
    Wuest, Frank
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (06) : 1823 - 1826
  • [8] Computational and anti-tumor studies of 7a-Aza-B-homostigmast-5-eno [7a, 7-d] tetrazole-3β-yl chloride
    Alam, Mahboob
    Alam, Mohammad Jane
    Nami, Shahab A. A.
    Lee, Dong-Ung
    Azam, Mohammad
    Ahmad, Shabbir
    [J]. JOURNAL OF MOLECULAR STRUCTURE, 2016, 1108 : 411 - 426
  • [9] Synthesis, characterization, X-ray diffraction, antimicrobial and in vitro cytotoxicity studies of 7a-Aza-B-homostigmast-5-eno [7a,7-d] tetrazole
    Alam, Mahboob
    Nami, Shahab A. A.
    Husain, Ahmad
    Lee, Dong-Ung
    Park, Soonheum
    [J]. COMPTES RENDUS CHIMIE, 2013, 16 (03) : 201 - 206
  • [10] The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases
    Alexander, Jessica P.
    Cravatt, Benjamin F.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (30) : 9699 - 9704
12345678910