Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus

被引：13

作者：

Wang, Xiaoling ^{[1
]}

Tabudravu, Jioji ^{[1
]}

Rateb, Mostafa Ezzat ^{[1
,3
]}

Annand, Krystal Joan ^{[1
]}

Qin, Zhiwei ^{[1
]}

Jaspars, Marcel ^{[1
]}

Deng, Zixin ^{[2
]}

Yu, Yi ^{[2
]}

Deng, Hai ^{[1
]}

机构：

[1] Univ Aberdeen, Marine Biodiscovery Ctr, Dept Chem, Aberdeen AB24 3LZ, Scotland

[2] Wuhan Univ, Sch Pharmaceut Sci, Key Lab Combinatory Biosynth & Drug Discovery, Minist Educ, Wuhan 430071, Peoples R China

[3] Beni Suef Univ, Fac Pharm, Dept Pharmacognosy, Bani Suwayf 62111, Egypt

来源：

MOLECULAR BIOSYSTEMS | 2013年 / 9卷 / 06期

基金：

中国国家自然科学基金;

关键词：

HALOGENATION; BIOSYNTHESIS; SYRB2;

D O I：

10.1039/c3mb70081j

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gene cluster directing actinomycin G biosynthesis in Streptomyces iakyrus has been identified and sequenced. It contains one actinomycin synthetase I (ACMS I) gene and two copies of ACMS II and III genes. Genetic analysis demonstrates a unique partnership between the putative hydroxylation and chlorination activities as both acmG8 and acmG9 genes need to be transcribed for the biosynthesis of actinomycin G(2-3), respectively.

引用

页码：1286 / 1289

页数：4

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