Lithocaldehydes A and B, polyketones from the deep sea-derived fungusPhomopsis lithocarpusFS508

被引：7

作者：

Liu, Huibo ^{[1
,2
]}

Liu, Zhaoming ^{[1
]}

Li, Haohua ^{[1
]}

Tan, Haibo ^{[3
]}

Zhang, Qingbo ^{[4
]}

Li, Dongli ^{[2
]}

Liu, Hongxin ^{[1
]}

Zhang, Weimin ^{[1
]}

机构：

[1] Guangdong Inst Microbiol, Guangdong Open Lab Appl Microbiol, State Key Lab Appl Microbiol Southern China, Guangdong Prov Key Lab Microbial Culture Collect, Guangzhou 510070, Peoples R China

[2] Wuyi Univ, Sch Chem & Environm Engn, Jiangmen 529020, Peoples R China

[3] Chinese Acad Sci, Guangdong Prov Key Lab Appl Bot, South China Bot Garden, Program Nat Prod Chem Biol,Key Lab Plant Resource, Guangzhou 510650, Peoples R China

[4] Chinese Acad Sci, South China Sea Inst Oceanol, South China Sea Resource Exploitat & Protect Coll, Guangdong Key Lab Marine Mat Med,CAS Key Lab Trop, Guangzhou 510301, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2020年 / 18卷 / 37期

基金：

中国国家自然科学基金;

关键词：

A-D; 4; PHOMOPSIS; INHIBITORS;

D O I：

10.1039/d0ob01674h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lithocaldehydes A (1) and B (2), a pair of novel diastereoisomers possessing an unprecedented 6/6/5/5/6 highly-fused ring system forming an earring-like skeleton, were isolated from the deep sea-derived fungusPhomopsis lithocarpusFS508. The structures of1and2were fully characterized and established through extensive spectroscopic interpretations and ECD calculations. Moreover, compounds1and2were shown to be promising antibiotics, exhibiting potent antifungal activities that are comparable to those of the positive control nystatin.

引用

页码：7326 / 7329

页数：4

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