Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study

被引：17

作者：

Meidtner, Karina ^{[1
,2
]}

Podmore, Clara ^{[3
]}

Kroger, Janine ^{[1
]}

van der Schouw, Yvonne T. ^{[4
]}

Bendinelli, Benedetta ^{[5
]}

Agnoli, Claudia ^{[6
]}

Arriola, Larraitz ^{[7
,8
,9
]}

Barricarte, Aurelio ^{[9
,10
,11
]}

Boeing, Heiner ^{[12
]}

Cross, Amanda J. ^{[13
]}

Dow, Courtney ^{[14
,15
,16
]}

Ekblom, Kim ^{[17
]}

Fagherazzi, Guy ^{[14
,15
,16
]}

Franks, Paul W. ^{[18
,19
]}

Gunter, Marc J. ^{[20
]}

Huerta, Jose Maria ^{[8
,21
]}

Jakszyn, Paula ^{[22
,23
]}

Jenab, Mazda ^{[20
]}

Katzke, Verena A. ^{[24
]}

Key, Timothy J. ^{[25
]}

Khaw, Kay Tee ^{[26
]}

Kuhn, Tilman ^{[24
]}

Kyro, Cecilie ^{[27
]}

Mancini, Francesca Romana ^{[14
,15
,16
]}

Melander, Olle ^{[18
]}

Nilsson, Peter M. ^{[18
]}

Overvad, Kim ^{[28
,29
]}

Palli, Domenico ^{[5
]}

Panico, Salvatore ^{[30
]}

Quiros, J. Ramon ^{[31
]}

Rodriguez-Barranco, Miguel ^{[9
,32
]}

Sacerdote, Carlotta ^{[33
,34
,35
]}

Sluijs, Ivonne ^{[4
]}

Stepien, Magdalena ^{[20
]}

Tjonneland, Anne ^{[27
]}

Tumino, Rosario ^{[36
,37
]}

Forouhi, Nita G. ^{[3
]}

Sharp, Stephen J. ^{[3
]}

Langenberg, Claudia ^{[3
]}

Schulze, Matthias B. ^{[1
,2
]}

Riboli, Elio ^{[13
]}

Wareham, Nicholas J. ^{[3
]}

机构：

[1] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

[2] German Ctr Diabet Res DZD, Munich, Germany

[3] Univ Cambridge, Med Res Council Epidemiol Unit, Cambridge, England

[4] Univ Med Ctr Utrecht, Utrecht, Netherlands

[5] Canc Res & Prevent Inst ISPO, Florence, Italy

[6] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[7] Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[8] Basque Govt, Inst BIO Donostia, San Sebastian, Spain

[9] Consorcio Ctr Invest Biomed Red Epidemiol & Salud, Madrid, Spain

[10] Navarre Publ Hlth Inst ISPN, Pamplona, Spain

[11] Navarra Inst Hlth Res IdiSNA Pamplona, Navarra, Spain

[12] German Inst Human Nutr Potsdam Rehbrucke, Nuthetal, Germany

[13] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[14] Ctr Rech Epidemiol & Sante Populat, INSERM U1018, Villejuif, France

[15] Univ Paris Sud, Univ Paris Saclay, Villejuif, France

[16] Gustave Roussy Inst, Villejuif, France

[17] Umea Univ, Clin Chem, Dept Med Biosci, Umea, Sweden

[18] Lund Univ, Dept Clin Sci, Malmo, Sweden

[19] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[20] Int Agcy Res Canc, Lyon, France

[21] Murcia Reg Hlth Council, Inst Murciano Invest Biosanitaria Arrixaca, Dept Epidemiol, Murcia, Spain

[22] Catalan Inst Oncol ICO, Nutr & Canc Unit, Canc Epidemiol Res Programme, Barcelona, Spain

[23] Univ Ramon Llull, Blanquerna Hlth Sci Fac, Barcelona, Spain

[24] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[25] Univ Oxford, Oxford, England

[26] Univ Cambridge, Cambridge, England

[27] Danish Canc Soc, Res Ctr, Copenhagen, Denmark

[28] Aarhus Univ, Dept Publ Hlth, Sect Epidemiol, Aarhus, Denmark

[29] Aalborg Univ Hosp, Aalborg, Denmark

[30] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[31] Publ Hlth Directorate, Asturias, Spain

[32] Univ Granada, Hosp Univ Granada, Escuela Andaluza Salud Publ, Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain

[33] Univ Turin, Citta Salute & Sci Hosp, Unit Canc Epidemiol, Turin, Italy

[34] Ctr Canc Prevent CPO, Turin, Italy

[35] Human Genet Fdn HuGeF, Turin, Italy

[36] Azienda Sanit Prov Ragusa, Ragusa, Italy

[37] Org Non Lucrat Utilita Sociale, Assoc Iblea Ric Epidemiol, Ragusa, Italy

来源：

DIABETES CARE | 2018年 / 41卷 / 02期

基金：

英国惠康基金; 英国医学研究理事会; 瑞典研究理事会;

关键词：

MEAT CONSUMPTION; ASSOCIATION; PROJECT; CANCER; POLYMORPHISMS; TRANSFERRIN; METABOLISM; FERRITIN; STORES; HEME;

D O I：

10.2337/dc17-1080

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes. RESEARCH DESIGN AND METHODS The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries. Single nucleotide polymorphisms (SNPs) were selected from genome-wide association studies on iron status biomarkers and candidate gene studies. A ferritin-related gene score was constructed. Multiplicative and additive interactions of heme iron and SNPs as well as the gene score were evaluated using Cox proportional hazards regression. RESULTS Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (beta = 0.113 [95% CI 0.082; 0.144]), but not with transferrin (-0.019 [-0.043; 0.006]) or transferrin saturation (0.016 [-0.006; 0.037]). Five SNPs located in four genes (rs1799945 [HFE H63D], rs1800562 [HFE C282Y], rs236918 [PCK7], rs744653 [SLC40A1], and rs855791 [TMPRSS6 V736A]) were associated with ferritin. We did not detect an interaction of heme iron and the gene score on the risk of diabetes in the overall study population (P-add = 0.16, P-mult = 0.21) but did detect a trend toward a negative interaction in men (P-add = 0.04, P-mult = 0.03). CONCLUSIONS We found no convincing evidence that the interplay of dietary and genetic factors related to body iron status associates with type 2 diabetes risk above the level expected from the sum or product of the two individual exposures.

引用

页码：277 / 285

页数：9

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