Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study

被引：17

作者：

Meidtner, Karina ^{[1
,2
]}

Podmore, Clara ^{[3
]}

Kroger, Janine ^{[1
]}

van der Schouw, Yvonne T. ^{[4
]}

Bendinelli, Benedetta ^{[5
]}

Agnoli, Claudia ^{[6
]}

Arriola, Larraitz ^{[7
,8
,9
]}

Barricarte, Aurelio ^{[9
,10
,11
]}

Boeing, Heiner ^{[12
]}

Cross, Amanda J. ^{[13
]}

Dow, Courtney ^{[14
,15
,16
]}

Ekblom, Kim ^{[17
]}

Fagherazzi, Guy ^{[14
,15
,16
]}

Franks, Paul W. ^{[18
,19
]}

Gunter, Marc J. ^{[20
]}

Huerta, Jose Maria ^{[8
,21
]}

Jakszyn, Paula ^{[22
,23
]}

Jenab, Mazda ^{[20
]}

Katzke, Verena A. ^{[24
]}

Key, Timothy J. ^{[25
]}

Khaw, Kay Tee ^{[26
]}

Kuhn, Tilman ^{[24
]}

Kyro, Cecilie ^{[27
]}

Mancini, Francesca Romana ^{[14
,15
,16
]}

Melander, Olle ^{[18
]}

Nilsson, Peter M. ^{[18
]}

Overvad, Kim ^{[28
,29
]}

Palli, Domenico ^{[5
]}

Panico, Salvatore ^{[30
]}

Quiros, J. Ramon ^{[31
]}

Rodriguez-Barranco, Miguel ^{[9
,32
]}

Sacerdote, Carlotta ^{[33
,34
,35
]}

Sluijs, Ivonne ^{[4
]}

Stepien, Magdalena ^{[20
]}

Tjonneland, Anne ^{[27
]}

Tumino, Rosario ^{[36
,37
]}

Forouhi, Nita G. ^{[3
]}

Sharp, Stephen J. ^{[3
]}

Langenberg, Claudia ^{[3
]}

Schulze, Matthias B. ^{[1
,2
]}

Riboli, Elio ^{[13
]}

Wareham, Nicholas J. ^{[3
]}

机构：

[1] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

[2] German Ctr Diabet Res DZD, Munich, Germany

[3] Univ Cambridge, Med Res Council Epidemiol Unit, Cambridge, England

[4] Univ Med Ctr Utrecht, Utrecht, Netherlands

[5] Canc Res & Prevent Inst ISPO, Florence, Italy

[6] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[7] Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[8] Basque Govt, Inst BIO Donostia, San Sebastian, Spain

[9] Consorcio Ctr Invest Biomed Red Epidemiol & Salud, Madrid, Spain

[10] Navarre Publ Hlth Inst ISPN, Pamplona, Spain

[11] Navarra Inst Hlth Res IdiSNA Pamplona, Navarra, Spain

[12] German Inst Human Nutr Potsdam Rehbrucke, Nuthetal, Germany

[13] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[14] Ctr Rech Epidemiol & Sante Populat, INSERM U1018, Villejuif, France

[15] Univ Paris Sud, Univ Paris Saclay, Villejuif, France

[16] Gustave Roussy Inst, Villejuif, France

[17] Umea Univ, Clin Chem, Dept Med Biosci, Umea, Sweden

[18] Lund Univ, Dept Clin Sci, Malmo, Sweden

[19] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[20] Int Agcy Res Canc, Lyon, France

[21] Murcia Reg Hlth Council, Inst Murciano Invest Biosanitaria Arrixaca, Dept Epidemiol, Murcia, Spain

[22] Catalan Inst Oncol ICO, Nutr & Canc Unit, Canc Epidemiol Res Programme, Barcelona, Spain

[23] Univ Ramon Llull, Blanquerna Hlth Sci Fac, Barcelona, Spain

[24] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[25] Univ Oxford, Oxford, England

[26] Univ Cambridge, Cambridge, England

[27] Danish Canc Soc, Res Ctr, Copenhagen, Denmark

[28] Aarhus Univ, Dept Publ Hlth, Sect Epidemiol, Aarhus, Denmark

[29] Aalborg Univ Hosp, Aalborg, Denmark

[30] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[31] Publ Hlth Directorate, Asturias, Spain

[32] Univ Granada, Hosp Univ Granada, Escuela Andaluza Salud Publ, Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain

[33] Univ Turin, Citta Salute & Sci Hosp, Unit Canc Epidemiol, Turin, Italy

[34] Ctr Canc Prevent CPO, Turin, Italy

[35] Human Genet Fdn HuGeF, Turin, Italy

[36] Azienda Sanit Prov Ragusa, Ragusa, Italy

[37] Org Non Lucrat Utilita Sociale, Assoc Iblea Ric Epidemiol, Ragusa, Italy

来源：

DIABETES CARE | 2018年 / 41卷 / 02期

基金：

英国惠康基金; 英国医学研究理事会; 瑞典研究理事会;

关键词：

MEAT CONSUMPTION; ASSOCIATION; PROJECT; CANCER; POLYMORPHISMS; TRANSFERRIN; METABOLISM; FERRITIN; STORES; HEME;

D O I：

10.2337/dc17-1080

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes. RESEARCH DESIGN AND METHODS The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries. Single nucleotide polymorphisms (SNPs) were selected from genome-wide association studies on iron status biomarkers and candidate gene studies. A ferritin-related gene score was constructed. Multiplicative and additive interactions of heme iron and SNPs as well as the gene score were evaluated using Cox proportional hazards regression. RESULTS Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (beta = 0.113 [95% CI 0.082; 0.144]), but not with transferrin (-0.019 [-0.043; 0.006]) or transferrin saturation (0.016 [-0.006; 0.037]). Five SNPs located in four genes (rs1799945 [HFE H63D], rs1800562 [HFE C282Y], rs236918 [PCK7], rs744653 [SLC40A1], and rs855791 [TMPRSS6 V736A]) were associated with ferritin. We did not detect an interaction of heme iron and the gene score on the risk of diabetes in the overall study population (P-add = 0.16, P-mult = 0.21) but did detect a trend toward a negative interaction in men (P-add = 0.04, P-mult = 0.03). CONCLUSIONS We found no convincing evidence that the interplay of dietary and genetic factors related to body iron status associates with type 2 diabetes risk above the level expected from the sum or product of the two individual exposures.

引用

页码：277 / 285

页数：9

共 50 条

[1] Age at Menarche and Type 2 Diabetes Risk The EPIC-InterAct study
Elks, Cathy E.
Ong, Ken K.
Scott, Robert A.
van der Schouw, Yvonne T.
Brand, Judith S.
Wark, Petra A.
Amiano, Pilar
Balkau, Beverley
Barricarte, Aurelio
Boeing, Heiner
Fonseca-Nunes, Ana
Franks, Paul W.
Grioni, Sara
Halkjaer, Jytte
Kaaks, Rudolf
Key, Timothy J.
Khaw, Kay Tee
Mattiello, Amalia
Nilsson, Peter M.
Overvad, Kim
Palli, Domenico
Quiros, J. Ramon
Rinaldi, Sabina
Rolandsson, Olov
Romieu, Isabelle
Sacerdote, Carlotta
Sanchez, Maria-Jose
Spijkerman, Annemieke M. W.
Tjonneland, Anne
Tormo, Maria-Jose
Tumino, Rosario
Daphne, L. Van der A.
Forouhi, Nita G.
Sharp, Stephen J.
Langenberg, Claudia
Riboli, Elio
Wareham, Nicholas J.
DIABETES CARE, 2013, 36 (11) : 3526 - 3534
[2] The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors: the EPIC-InterAct study
Scott, R. A.
DIABETOLOGIA, 2013, 56 (01) : 60 - 69
[3] Association between dietary meat consumption and incident type 2 diabetes: the EPIC-InterAct study
Palli, D.
DIABETOLOGIA, 2013, 56 (01) : 47 - 59
[4] Adherence to predefined dietary patterns and incident type 2 diabetes in European populations: EPIC-InterAct Study
Kroeger, Janine
Schulze, Matthias B.
Romaguera, Dora
Guevara, Marcela
Buijsse, Brian
Boeing, Heiner
Beulens, Joline W. J.
Feskens, Edith J. M.
Amiano, Pilar
Ardanaz, Eva
Agnoli, Claudia
Buckland, Genevieve
Clavel-Chapelon, Francoise
Dahm, Christina C.
Fagherazzi, Guy
Franks, Paul W.
Kaaks, Rudolf
Key, Timothy J.
Khaw, Kay Tee
Lajous, Martin
Mattiello, Amalia
Menendez Garcia, Virginia
Navarro, Carmen
Nilsson, Peter M.
Overvad, Kim
Palli, Domenico
Ricceri, Fulvio
Rolandsson, Olov
Sanchez, Maria-Jose
Slimani, Nadia
Spijkerman, Annemieke M. W.
Tjonneland, Anne
Tumino, Rosario
van der A, Daphne L.
Langenberg, Claudia
Sharp, Stephen J.
Forouhi, Nita G.
Riboli, Elio
Wareham, Nicholas J.
DIABETOLOGIA, 2014, 57 (02) : 321 - 333
[5] The Association Between Dietary Flavonoid and Lignan Intakes and Incident Type 2 Diabetes in European Populations The EPIC-InterAct study
Zamora-Ros, Raul
Forouhi, Nita G.
Sharp, Stephen J.
Gonzalez, Carlos A.
Buijsse, Brian
Guevara, Marcela
van der Schouw, Yvonne T.
Amiano, Pilar
Boeing, Heiner
Bredsdorff, Lea
Clavel-Chapelon, Francoise
Fagherazzi, Guy
Feskens, Edith J.
Franks, Paul W.
Grioni, Sara
Katzke, Verena
Key, Timothy J.
Khaw, Kay-Tee
Kuehn, Tilman
Masala, Giovanna
Mattiello, Amalia
Molina-Montes, Esther
Nilsson, Peter M.
Overvad, Kim
Perquier, Florence
Ramon Quiros, J.
Romieu, Isabelle
Sacerdote, Carlotta
Scalbert, Augustin
Schulze, Matthias
Slimani, Nadia
Spijkerman, Annemieke M. W.
Tjonneland, Anne
Jose Tormo, Maria
Tumino, Rosario
van der A, Daphne L.
Langenberg, Claudia
Riboli, Elio
Wareham, Nicholas J.
DIABETES CARE, 2013, 36 (12) : 3961 - 3970
[6] Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study
Abbas, S.
Linseisen, J.
Rohrmann, S.
Beulens, J. W. J.
Buijsse, B.
Amiano, P.
Ardanaz, E.
Balkau, B.
Boeing, H.
Clavel-Chapelon, F.
Fagherazzi, G.
Franks, P. W.
Gavrila, D.
Grioni, S.
Kaaks, R.
Key, T. J.
Khaw, K. T.
Kuehn, T.
Mattiello, A.
Molina-Montes, E.
Nilsson, P. M.
Overvad, K.
Quiros, J. R.
Rolandsson, O.
Sacerdote, C.
Saieva, C.
Slimani, N.
Sluijs, I.
Spijkerman, A. M. W.
Tjonneland, A.
Tumino, R.
van der A, D. L.
Zamora-Ros, R.
Sharp, S. J.
Langenberg, C.
Forouhi, N. G.
Riboli, E.
Wareham, N. J.
EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2014, 68 (02) : 196 - 202
[7] Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study
Beulens, J. W. J.
van der Schouw, Y. T.
Bergmann, M. M.
Rohrmann, S.
Schulze, M. B.
Buijsse, B.
Grobbee, D. E.
Arriola, L.
Cauchi, S.
Tormo, M-J
Allen, N. E.
van der A, D. L.
Balkau, B.
Boeing, H.
Clavel-Chapelon, F.
de Lauzon-Guillan, B.
Franks, P.
Froguel, P.
Gonzales, C.
Halkjaer, J.
Huerta, J. M.
Kaaks, R.
Key, T. J.
Khaw, K. T.
Krogh, V.
Molina-Montes, E.
Nilsson, P.
Overvad, K.
Palli, D.
Panico, S.
Ramon Quiros, J.
Ronaldsson, O.
Romieu, I.
Romaguera, D.
Sacerdote, C.
Sanchez, M-J
Spijkerman, A. M. W.
Teucher, B.
Tjonneland, A.
Tumino, R.
Sharp, S.
Forouhi, N. G.
Langenberg, C.
Feskens, E. J. M.
Riboli, E.
Wareham, N. J.
JOURNAL OF INTERNAL MEDICINE, 2012, 272 (04) : 358 - 370
[8] Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study
van Nielen, Monique
Feskens, Edith J. M.
Mensink, Marco
Sluijs, Ivonne
Molina, Esther
Amiano, Pilar
Ardanaz, Eva
Balkau, Beverly
Beulens, Joline W. J.
Boeing, Heiner
Clavel-Chapelon, Francoise
Fagherazzi, Guy
Franks, Paul W.
Halkjaer, Jytte
Maria Huerta, Jose
Katzke, Verena
Key, Timothy J.
Khaw, Kay Tee
Krogh, Vittorio
Kuhn, Tilman
Menendez, Virginia V. M.
Nilsson, Peter
Overvad, Kim
Palli, Domenico
Panico, Salvatore
Rolandsson, Olov
Romieu, Isabelle
Sacerdote, Carlotta
Sanchez, Maria-Jose
Schulze, Matthias B.
Spijkerman, Annemieke M. W.
Tjonneland, Anne
Tumino, Rosario
Daphne, L. van der A.
Wurtz, Anne M. L.
Zamora-Ros, Raul
Langenberg, Claudia
Sharp, Stephen J.
Forouhi, Nita G.
Riboli, Elio
Wareham, Nicholas J.
DIABETES CARE, 2014, 37 (07) : 1854 - 1862
[9] The Association between Dietary Energy Density and Type 2 Diabetes in Europe: Results from the EPIC-InterAct Study
van den Berg, Saskia W.
van der A, Daphne L.
Spijkerman, Annemieke M. W.
van Woudenbergh, Geertruida J.
Tijhuis, Mariken J.
Amiano, Pilar
Ardanaz, Eva
Beulens, Joline W. J.
Boeing, Heiner
Clavel-Chapelon, Francoise
Crowe, Francesca L.
de Lauzon-Guillain, Blandine
Fagherazzi, Guy
Franks, Paul W.
Freisling, Heinz
Gonzalez, Carlos
Grioni, Sara
Halkjaer, Jytte
Maria Huerta, Jose
Huybrechts, Inge
Kaaks, Rudolf
Khaw, Kay Tee
Masala, Giovanna
Nilsson, Peter M.
Overvad, Kim
Panico, Salvatore
Ramon Quiros, J.
Rolandsson, Olov
Sacerdote, Carlotta
Sanchez, Maria-Jose
Schulze, Matthias B.
Slimani, Nadia
Struijk, Ellen A.
Tjonneland, Anne
Tumino, Rosario
Sharp, Stephen J.
Langenberg, Claudia
Forouhi, Nita G.
Feskens, Edith J. M.
Riboli, Elio
Wareham, Nicholas J.
PLOS ONE, 2013, 8 (05):
[10] Replacement of Red and Processed Meat With Other Food Sources of Protein and the Risk of Type 2 Diabetes in European Populations: The EPIC-InterAct Study
Ibsen, Daniel B.
Steur, Marinka
Imamura, Fumiaki
Overvad, Kim
Schulze, Matthias B.
Bendinelli, Benedetta
Guevara, Marcela
Agudo, Antonio
Amiano, Pilar
Aune, Dagfinn
Barricarte, Aurelio
Ericson, Ulrika
Fagherazzi, Guy
Franks, Paul W.
Freisling, Heinz
Quiros, Jose R.
Grioni, Sara
Heath, Alicia K.
Huybrechts, Inge
Katze, Verena
Laouali, Nasser
Mancini, Francesca
Masala, Giovanna
Olsen, Anja
Papier, Keren
Ramne, Stina
Rolandsson, Olov
Sacerdote, Carlotta
Sanchez, Maria-Jose
Santiuste, Carmen
Simeon, Vittorio
Spijkerman, Annemieke M. W.
Srour, Bernard
Tjonneland, Anne
Tong, Tammy Y. N.
Tumino, Rosario
van der Schouw, Yvonne T.
Weiderpass, Elisabete
Wittenbecher, Clemens
Sharp, Stephen J.
Riboli, Elio
Forouhi, Nita G.
Wareham, Nick J.
DIABETES CARE, 2020, 43 (11) : 2660 - 2667

← 1 2 3 4 5 →