Efficacy of all-trans retinoid acid in preventing nickel induced cardiotoxicity in myocardial cells of rats

被引：14
作者：
Lou, Siyue [1 ]
Zhong, Like [1 ]
Yang, Xiaochun [2 ]
Xue, Tao [1 ]
Gai, Renhua [2 ]
Zhu, Difeng [2 ]
Zhao, Yuqin [1 ]
Yang, Bo [1 ]
Ying, Meidan [1 ]
He, Qiaojun [1 ,2 ]
机构：
[1] Zhejiang Univ, Coll Pharmaceut Sci, Inst Pharmacol & Toxicol, Hangzhou 310058, Zhejiang, Peoples R China
[2] Zhejiang Univ, Ctr Drug Safety Evaluat & Res, Hangzhou 310058, Zhejiang, Peoples R China
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2013年 / 51卷
基金：
中国国家自然科学基金;
关键词：
Nickel; All-trans retinoid acid; Cardiotoxicity; Mitogen-activated protein kinases; Reactive oxygen species; ACTIVATED PROTEIN-KINASE; RENIN-ANGIOTENSIN SYSTEM; OXIDATIVE STRESS; INDUCED APOPTOSIS; GENE-EXPRESSION; PARTICULATE; PATHWAY; NANOPARTICLES; HEART; CARDIOMYOCYTES;
D O I：
10.1016/j.fct.2012.09.007
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Nickel, a metal commonly found in battery plants and welding factories, has potential cardiotoxicity, while all-trans retinoid acid (atRA) can promote cardiovascular repair and myocardial recovery. The purpose of this study was to investigate whether atRA could prevent cardiotoxicity induced by nickel both in vitro and in vivo. In the study, a rat myocardial cell line (H9c2) exposed to different concentrations of nickel chloride (NiCl2) displayed apoptotic features accompanied by reactive oxygen species generation. In addition, NiCl2 also caused obvious apoptosis and systolic dysfunction in primary myocardial cells. Treatment with atRA efficiently attenuated the cytotoxicities triggered by NiCl2 as it significantly mitigated ROS generation and decreased MAP kinases activity in NiCl2-treated cardiomyocytes. Additionally, NiCl2 exposure caused obvious arrhythmia in Sprague-Dawley rats with the maximum tolerance dose of NiCl2 between 2 and 3 mg/kg. A combinational intragastric administration of 40 mg/kg atRA can partially reverse NiCl2-induced arrhythmia in rats. Our results suggested that atRA might have therapeutic potential in alleviating the adverse effects of nickel on the cardiovascular system. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：251 / 258
页数：8
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