Earthquake in the presence of flood-induced scour is a critical multihazard scenario for bridges located in seismically-active, flood-prone regions. The present article evaluates seismic performance of four example reinforced concrete bridges when they are pre-exposed to regional flood hazards. Nonlinear time history analyses of the example bridges are performed for a suite of ground motion time histories in the presence and absence of scour expected from different intensity flood events. Fragility analysis is performed to develop seismic fragility curves of the example bridges for various scour depths. Results show nonlinear increase in bridge seismic fragility with increase in scour depth.