Bioactive compounds fromPhysalis angulataand their anti-inflammatory and cytotoxic activities

被引：12

作者：

Hoang Le Tuan Anh ^{[1
,2
]}

Vinh Le Ba ^{[3
,4
]}

Thi Thao Do ^{[2
,5
]}

Van Kiem Phan ^{[3
]}

Hai Yen Pham Thi ^{[2
]}

Long Giang Bach ^{[6
]}

Manh Hung Tran ^{[7
]}

Phuong Anh Tran Thi ^{[2
]}

Kim, Young Ho ^{[4
]}

机构：

[1] Vietnam Acad Sci & Technol, Mientrung Inst Sci Res, 321 Huynh Thuc Khang, Hue City 531600, Thua Thien Hue, Vietnam

[2] Vietnam Acad Sci & Technol, Grad Univ Sci & Technol, Hanoi 10307, Vietnam

[3] Vietnam Acad Sci & Technol, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi 10307, Vietnam

[4] Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea

[5] Vietnam Acad Sci & Technol, Inst Biotechnol, 18 Hoang Quoc Viet, Hanoi 10307, Vietnam

[6] Nguyen Tat Thanh Univ, 300A Nguyen Tat Thanh, Ho Chi Minh City 748000, Vietnam

[7] Vietnam Natl Univ Hochiminh City, Univ Sci, Fac Chem, Med Chem Div, 227 Nguyen Van Cu, Ho Chi Minh City 748000, Vietnam

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2021年 / 23卷 / 08期

关键词：

Physalis angulate; solanaceae; physalucoside A; withanolides; anti-inflammatory; cytotoxic activity; PHYSALIS-ANGULATA;

D O I：

10.1080/10286020.2020.1825390

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new compound, physalucoside A (1), together with seven withanolides (2-8) and three flavonoids (9-11), were isolated fromPhysalis angulataL. (Solanaceae), a medicinal plant native to Vietnam. The chemical structures of these compounds were elucidated by one- and two-dimensional NMR spectra, high-resolution electrospray ionization mass spectrometry analyses, and chemical reactivity. The anti-inflammatory and cytotoxic activities of isolated compounds were also evaluated. These data suggest that the anti-inflammatory activity ofP. angulatais due primarily to its withanolide content. This study demonstrates the potential of withanolides as promising candidates for the development of new anti-inflammatory drugs.

引用

收藏

页码：809 / 817

页数：9

相关论文

共 50 条

[21] Anti-inflammatory, antioxidant, cytotoxic activities, and sesquiterpenoid contents of Paralemnalia thyrsoides [J].

Alassass, Aya Ali ;

Abubakr, Marwa S. ;

Alarif, Walied M. ;

Ayyad, Seif-Eldin N. ;

Mohammed, Abd-Elsalam E. .

PHARMACOGNOSY MAGAZINE, 2022, 18 (77) :188-192

[22] Cytotoxic and Anti-Inflammatory Activities of Garcinia xanthochymus Extracts on Cell Lines [J].

Hamidon, Hanisuhana ;

Taher, Muhammad ;

Jaffri, Juliana Md ;

Zakaria, Tg Muhamad Faris Syafiq Tg ;

Sulaiman, Wan M. A. W. ;

Susanti, Deny ;

Ichwan, Solachuddin J. A. ;

Zakaria, Zainul A. .

MAKARA JOURNAL OF HEALTH RESEARCH, 2016, 20 (01) :11-17

[23] In vitro and in silico elucidation of antidiabetic and anti-inflammatory activities of bioactive compounds from Momordica charantia L. [J].

Shivanagoudra, Siddanagouda R. ;

Perera, Wilmer H. ;

Perez, Jose L. ;

Athrey, Giridhar ;

Sun, Yuxiang ;

Wu, Chia Shan ;

Jayaprakasha, G. K. ;

Patil, Bhimanagouda S. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 27 (14) :3097-3109

[24] Anti-Inflammatory and Cytotoxic Compounds Isolated from Plants of Euphorbia Genus [J].

Rojas-Jimenez, Sarai ;

Valladares-Cisneros, Maria Guadalupe ;

Salinas-Sanchez, David Osvaldo ;

Perez-Ramos, Julia ;

Sanchez-Perez, Leonor ;

Perez-Gutierrez, Salud ;

Campos-Xolalpa, Nimsi .

MOLECULES, 2024, 29 (05)

[25] Bioactive Peptides from Milk Proteins with Antioxidant, Anti-Inflammatory, and Antihypertensive Activities [J].

Borges, Thais ;

Coelho, Pedro ;

Prudencio, Cristina ;

Gomes, Ana ;

Gomes, Paula ;

Ferraz, Ricardo .

FOODS, 2025, 14 (03)

[26] Cytotoxic and Anti-Inflammatory Activities of Dihydroisocoumarin and Xanthone Derivatives from Garcinia picrorhiza [J].

Sukandar, Edwin R. ;

Kaennakam, Sutin ;

Raab, Pia ;

Noest, Xuehong ;

Rassamee, Kitiya ;

Bauer, Rudolf ;

Siripong, Pongpun ;

Ersam, Taslim ;

Tip-pyang, Santi ;

Chavasiri, Warinthorn .

MOLECULES, 2021, 26 (21)

[27] Antioxidant, Anti-inflammatory and Cytotoxic Activities of Polyphenols Extracted from Chroogomphus rutilus [J].

Zhang, Ye ;

Lan, Meng ;

Lue, Jin-Peng ;

Li, Jing-Feng ;

Zhang, Kai-Yue ;

Zhi, Hui ;

Zhang, Hui ;

Sun, Jia-Ming .

CHEMISTRY & BIODIVERSITY, 2020, 17 (01)

[28] Phenolic constituents with anti-inflammatory and cytotoxic activities from the rhizomes of Iris domestica [J].

Liu, Kai-Dong ;

Yang, Wan-Qi ;

Dai, Ming -Zhu ;

Xu, Yong ;

Qin, Yun-Peng ;

Dong, Ying-Ying ;

Fu, Jiang ;

Qu, Jing .

PHYTOCHEMISTRY, 2022, 203

[29] Tirucallane triterpenoids from the mastic (Pistacia lentiscus) and their anti-inflammatory and cytotoxic activities [J].

Liu, Wei ;

Gao, Jie ;

Li, Miaomiao ;

Aisa, Haji Akber ;

Yuan, Tao .

PHYTOCHEMISTRY, 2021, 182

[30] In Vitro Anti-Inflammatory, Anti-Oxidant, and Cytotoxic Activities of Four Curcuma Species and the Isolation of Compounds from Curcuma aromatica Rhizome [J].

Pintatum, Aknarin ;

Maneerat, Wisanu ;

Logie, Emilie ;

Tuenter, Emmy ;

Sakavitsi, Maria E. ;

Pieters, Luc ;

Vanden Berghe, Wim ;

Sripisut, Tawanun ;

Deachathai, Suwanna ;

Laphookhieo, Surat .

BIOMOLECULES, 2020, 10 (05)

← 1 2 3 4 5 →