Bioactive compounds fromPhysalis angulataand their anti-inflammatory and cytotoxic activities

A new compound, physalucoside A (1), together with seven withanolides (2-8) and three flavonoids (9-11), were isolated fromPhysalis angulataL. (Solanaceae), a medicinal plant native to Vietnam. The chemical structures of these compounds were elucidated by one- and two-dimensional NMR spectra, high-resolution electrospray ionization mass spectrometry analyses, and chemical reactivity. The anti-inflammatory and cytotoxic activities of isolated compounds were also evaluated. These data suggest that the anti-inflammatory activity ofP. angulatais due primarily to its withanolide content. This study demonstrates the potential of withanolides as promising candidates for the development of new anti-inflammatory drugs.