Synthesis, characterization and antibacterial screening of fluorinated benzofuran containing heterocycles

被引：0

作者：

Kundlikar, S. G. ^{[1
]}

Randhavane, P. V. ^{[1
]}

Akolkar, H. N. ^{[1
]}

Karale, B. K. ^{[1
]}

机构：

[1] Radhabai Kale Mahila Mahavidyalaya, PG Dept Chem, Ahmednagar 414001, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2019年 / 58卷 / 04期

关键词：

Benzofuran; chromones; pyrazoles; antibacterial activity; DERIVATIVES; POTENT; XANTHONES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-(4-Fluorophenyl)-5-phenylbenzofuran-3-carboxylic acid 1 when treated with substituted 2-hydroxyacetophenones 2 in dry pyridine and POC13 affords compound 3 which when reacted with pyridine/KOH by B. V. transformation gives 4. Compound 4 on refluxing with different reagents Ac20 in presence of sodium acetate, acetic acid in HC1, and hydrazinehydrate in alcohol gives 5, 6 and 7 respectively. The structures of all synthesized compounds have been confirmed by spectroscopic techniques. All the synthesized compounds have been screened for their antibacterial activity.

引用

页码：504 / 510

页数：7

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