Impact of obesity on cardiovascular health

被引：57

作者：

Chrostowska, Marzena ^{[1
]}

Szyndler, Anna ^{[1
]}

Hoffmann, Michal ^{[1
]}

Narkiewicz, Krzysztof ^{[1
]}

机构：

[1] Med Univ Gdansk, Dept Hypertens & Diabetol, PL-80952 Gdansk, Poland

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2013年 / 27卷 / 02期

关键词：

atherosclerosis; cardiovascular diseases; hypertension; obesity; risk factors; sleep apnea; BODY-MASS INDEX; OBSTRUCTIVE SLEEP-APNEA; INDEPENDENT RISK-FACTOR; INSULIN-RESISTANCE SYNDROME; CORONARY-HEART-DISEASE; TARGET ORGAN DAMAGE; FAT DISTRIBUTION; BLOOD-PRESSURE; ADIPOSE-TISSUE; UNITED-STATES;

D O I：

10.1016/j.beem.2013.01.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review examines the impact of obesity on cardiovascular health. We will review first, relationship between obesity and hypertension. Second, we will describe obesity-related subclinical abnormalities in cardiovascular function and structure. Third, we will summarize evidence linking obesity to overt cardiovascular disease including coronary artery disease, congestive heart failure, stroke, arrhythmias and sudden cardiac death. Fourth, we will discuss the potential mechanisms underlying increased cardiovascular risk in obese subjects. Last, we will discuss contribution of sleep apnea to the link between obesity and cardiovascular disease. Despite recent progress in understanding epidemiologic and pathophysiological links between obesity and cardiovascular disease, several issues remain to be addressed in the future studies. There is a clear need to identify better markers of obesity-related subclinical cardiovascular damage. Furthermore, we should improve identification of obese subjects at highest cardiovascular risk. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：147 / 156

页数：10

共 100 条

[1] Usefulness of Epicardial Adipose Tissue as Predictor of Cardiovascular Events in Patients With Coronary Artery Disease [J].

Albuquerque, Felipe N. ;

Somers, Virend K. ;

Blume, Gustavo ;

Miranda, William ;

Korenfeld, Yoel ;

Calvin, Andrew D. ;

Qin, Rui ;

Lopez-Jimenez, Francisco .

AMERICAN JOURNAL OF CARDIOLOGY, 2012, 110 (08) :1100-1105

[2] Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity [J].

Arcaro, G ;

Zamboni, M ;

Rossi, L ;

Turcato, E ;

Covi, G ;

Armellini, F ;

Bosello, O ;

Lechi, A .

INTERNATIONAL JOURNAL OF OBESITY, 1999, 23 (09) :936-942

[3] Clinical Relevance of Adipokines [J].

Blueher, Matthias .

DIABETES & METABOLISM JOURNAL, 2012, 36 (05) :317-327

[4] Association of overweight with increased risk of coronary heart disease partly independent of blood pressure and cholesterol levels - A meta-analysis of 21 cohort studies including more than 300,000 persons [J].

Bogers, Rik P. ;

Bemelmans, Wanda J. E. ;

Hoogenveen, Rudolf T. ;

Boshuizen, Hendriek C. ;

Woodward, Mark ;

Knekt, Paul ;

van Dam, Rob M. ;

Hu, Frank B. ;

Visscher, Tommy L. S. ;

Menotti, Alessandro ;

Thorpe, Roland J., Jr. ;

Jamrozik, Konrad ;

Calling, Susanna ;

Strand, Bjorn Heine ;

Shipley, Martin J. .

ARCHIVES OF INTERNAL MEDICINE, 2007, 167 (16) :1720-1728

[5] Impact of Body Mass Index and Waist Circumference on the Long-Term Risk of Diabetes Mellitus, Hypertension, and Cardiac Organ Damage [J].

Bombelli, Michele ;

Facchetti, Rita ;

Sega, Roberto ;

Carugo, Stefano ;

Fodri, Danilo ;

Brambilla, Gianmaria ;

Giannattasio, Cristina ;

Grassi, Guido ;

Mancia, Giuseppe .

HYPERTENSION, 2011, 58 (06) :1029-U113

[6] Usefulness of visceral obesity (waist/hip ratio) in predicting vascular endothelial function in healthy overweight adults [J].

Brook, RD ;

Bard, RL ;

Rubenfire, M ;

Ridker, PM ;

Rajagopalan, S .

AMERICAN JOURNAL OF CARDIOLOGY, 2001, 88 (11) :1264-1269

[7] Obstructive sleep apnea as a cause of systemic hypertension - Evidence from a canine model [J].

Brooks, D ;

Horner, RL ;

Kozar, LF ;

RenderTeixeira, CL ;

Phillipson, EA .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (01) :106-109

[8] Body mass index and the prevalence of hypertension and dyslipidemia [J].

Brown, CD ;

Higgins, M ;

Donato, KA ;

Rohde, FC ;

Garrison, R ;

Obarzanek, E ;

Ernst, ND ;

Horan, M .

OBESITY RESEARCH, 2000, 8 (09) :605-619

[9] Fat distribution, body mass index and blood pressure in 22 090 men and women in the Norfolk cohort of the European prospective investigation into cancer and nutrition (EPIC-Norfolk) study [J].

Canoy, D ;

Luben, R ;

Welch, A ;

Bingham, S ;

Wareham, N ;

Day, N ;

Khaw, KT .

JOURNAL OF HYPERTENSION, 2004, 22 (11) :2067-2074

[10] Progression of subclinical coronary atherosclerosis - Does obesity make a difference? [J].

Cassidy, AE ;

Bielak, LF ;

Zhou, Y ;

Sheedy, PF ;

Turner, ST ;

Breen, JF ;

Araoz, PA ;

Kullo, IJ ;

Lin, XH ;

Peyser, PA .

CIRCULATION, 2005, 111 (15) :1877-1882

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