The Anti-C1s Antibody TNT003 Prevents Complement Activation in the Skin Induced by Bullous Pemphigoid Autoantibodies

被引:38
作者
Kasprick, Anika [1 ]
Holtsche, Maike M. [2 ]
Rose, Eileen L. [3 ]
Hussain, Sami [3 ]
Schmidt, Enno [1 ,2 ]
Petersen, Frank [4 ]
Panicker, Sandip [3 ]
Ludwig, Ralf J. [1 ,2 ]
机构
[1] Univ Lubeck, Lubeck Inst Expt Dermatol, Lubeck, Germany
[2] Univ Lubeck, Dept Dermatol, Lubeck, Germany
[3] True North Therapeut Inc, San Francisco, CA USA
[4] Res Ctr Borstel, Prior Area Asthma & Allergy, Borstel, Germany
关键词
DISEASES;
D O I
10.1016/j.jid.2017.08.030
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
[No abstract available]
引用
收藏
页码:458 / 461
页数:5
相关论文
共 15 条
  • [1] Bernard P, 2009, ARCH DERMATOL, V145, P537, DOI 10.1001/archdermatol.2009.53
  • [2] Macropinocytosis of type XVII collagen induced by bullous pemphigoid IgG is regulated via protein kinase C
    Iwata, Hiroaki
    Kamaguchi, Mayumi
    Ujiie, Hideyuki
    Nishimura, Machiko
    Izumi, Kentaro
    Natsuga, Ken
    Shinkuma, Satoru
    Nishie, Wataru
    Shimizu, Hiroshi
    [J]. LABORATORY INVESTIGATION, 2016, 96 (12) : 1301 - 1310
  • [3] Animal Models to Investigate Pathomechanisms and Evaluate Novel Treatments for Autoimmune Bullous Dermatoses
    Iwata, Hiroaki
    Bieber, Katja
    Hirose, Misa
    Ludwig, Ralf J.
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2015, 21 (18) : 2422 - 2439
  • [4] Autoantibody Profile Differentiates between Inflammatory and Noninflammatory Bullous Pemphigoid
    Izumi, Kentaro
    Nishie, Wataru
    Mai, Yosuke
    Wada, Mayumi
    Natsuga, Ken
    Ujiie, Hideyuki
    Iwata, Hiroaki
    Yamagami, Jun
    Shimizu, Hiroshi
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2016, 136 (11) : 2201 - 2210
  • [5] Complement Fixation Test: An Update of an Old Method for Diagnosis of Bullous Pemphigoid
    Jankaskova, Jana
    Horvath, Orsolya N.
    Varga, Rita
    Ruzicka, Thomas
    Sardy, Miklos
    [J]. ACTA DERMATO-VENEREOLOGICA, 2016, 96 (02) : 197 - 201
  • [6] A comparison of oral and topical corticosteroids in patients with bullous pemphigoid
    Joly, P
    Roujeau, JC
    Benichou, J
    Picard, C
    Dreno, B
    Delaporte, E
    Vaillant, L
    D'Incan, M
    Plantin, P
    Bedane, C
    Young, P
    Bernard, P
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (05) : 321 - 327
  • [7] BASEMENT ZONE ANTIBODIES IN BULLOUS PEMPHIGOID
    JORDON, RE
    BEUTNER, EH
    WITEBSKY, E
    BLUMENTAL, G
    HALE, WL
    LEVER, WF
    [J]. JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1967, 200 (09) : 751 - +
  • [8] COMPLEMENT-SYSTEM IN BULLOUS PEMPHIGOID .2. IMMUNOFLUORESCENT EVIDENCE FOR BOTH CLASSICAL AND ALTERNATE-PATHWAY ACTIVATION
    JORDON, RE
    SCHROETER, AL
    GOOD, RA
    DAY, NK
    [J]. CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1975, 3 (03): : 307 - 314
  • [9] Human IgG1 Monoclonal Antibody against Human Collagen 17 Noncollagenous 16A Domain Induces Blisters via Complement Activation in Experimental Bullous Pemphigoid Model
    Li, Qiang
    Ujiie, Hideyuki
    Shibaki, Akihiko
    Wang, Gang
    Moriuchi, Reine
    Qiao, Hong-jiang
    Morioka, Hiroshi
    Shinkuma, Satoru
    Natsuga, Ken
    Long, Heather A.
    Nishie, Wataru
    Shimizu, Hiroshi
    [J]. JOURNAL OF IMMUNOLOGY, 2010, 185 (12) : 7746 - 7755
  • [10] Emerging treatments for pemphigoid diseases
    Ludwig, Ralf J.
    Kalies, Kathrin
    Koehl, Joerg
    Zillikens, Detlef
    Schmidt, Enno
    [J]. TRENDS IN MOLECULAR MEDICINE, 2013, 19 (08) : 501 - 512