A fruitful decade from 2005 to 2014 for anthraquinone patents

被引：44

作者：

Hussain, Hidayat ^{[1
]}

Al-Harrasi, Ahmed ^{[1
]}

Al-Rawahi, Ahmed ^{[1
]}

Green, Ivan R. ^{[2
]}

Csuk, Rene ^{[3
]}

Ahmed, Ishtiaq ^{[4
]}

Shah, Afzah ^{[5
]}

Abbas, Ghulam ^{[1
]}

Rehman, Najeeb Ur ^{[1
]}

Ullah, Riaz ^{[6
]}

机构：

[1] Univ Nizwa, UoN Chair Omans Med Plants & Marine Nat Prod, Birkat Al Mauz 616, Nizwa, Oman

[2] Univ Stellenbosch, Dept Chem & Polymer Sci, ZA-7600 Stellenbosch, South Africa

[3] Univ Halle Wittenberg, Organ Chem, D-06120 Halle, Germany

[4] Karlsruhe Inst Technol, DFG Ctr Funct Nanostruct, D-76131 Karlsruhe, Germany

[5] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan

[6] Govt Coll Ara Khel, Dept Chem, FR Kohat, KPK, Pakistan

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2015年 / 25卷 / 09期

关键词：

anthraquinone; antibacterial; anticancer; antidiabetic; antifibrotic; anti-HCV; anti-inflammatory; antiviral; apoptosis; fungicidal;

D O I：

10.1517/13543776.2015.1050793

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Introduction: Anthraquinones are aromatic compounds whose structures are related to anthracene (parent structure: 9,10-dioxoanthracene) for which various methods for their synthesis have been developed. In the past decade (2005-2014), much work has been done regarding anthraquinone chemistry in order to discover new compounds related to this scaffold as anticancer, antibacterial, antidiabetic, antiviral, anti-HCV, antifibrotic, fungicidal and anti-inflammatory agents. Areas covered: This review covers the patents on therapeutic activities of anthraquinones and their derivatives in the years between 2005 and 2014. A large portion of the therapeutic applications that were reported in international patents will be presented and discussed. Although a large number of patents have been registered over the last decade, this review is focused on important patents related to cancer, inflammation, infectious diseases, diabetic conditions and hepatitis C. Expert opinion: The tricyclic planar ring system of anthraquinones displays a wide range of important pharmaceutical properties. By linking active anthraquinone analogs to other important pharmacophores or conjugates such as oximes, N-heterocycles, benzodiazepines or glycosyl ethers, their anticancer potential is enhanced. The ability of anthraquinone analogs to become more prominent as novel pharmaceutical agents may further be enhanced by fusing functionalized heterocyclic rings onto established anthraquinone cores.

引用

页码：1053 / 1064

页数：12

共 54 条

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