Therapeutic and immune effects of 5-aminolevulinic acid photodynamic therapy on UVB-induced squamous cell carcinomas in hairless mice

被引：55

作者：

Wang, Hongwei ^{[1
,2
]}

Li, Jingjing ^{[1
]}

Lv, Ting ^{[1
,2
]}

Tu, Qingfeng ^{[1
]}

Huang, Zheng ^{[3
,4
,5
]}

Wang, Xiuli ^{[1
]}

机构：

[1] Shanghai Skin Dis Hosp, Dept Dermatol & Venereol, Shanghai, Peoples R China

[2] Shanghai Huadong Hosp, Dept Dermatol, Shanghai, Peoples R China

[3] Univ Colorado, CAPT Lab, Denver, CO 80202 USA

[4] Univ Colorado, Ctr Canc, Denver, CO 80262 USA

[5] Fujian Normal Univ, MOE Key Lab OptoElect Sci & Technol Med, Fujian Prov Key Lab Photon Technol, Fuzhou, Peoples R China

来源：

EXPERIMENTAL DERMATOLOGY | 2013年 / 22卷 / 05期

关键词：

5-aminolevulinic acid; hairless mouse; immune responses; squamous cell carcinoma; topical photodynamic therapy; UVB; AMINOLEVULINIC ACID; SKIN TUMORS; PDT; FLUORESCENCE; LIGHT;

D O I：

10.1111/exd.12132

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The therapeutic effects of 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) on cutaneous squamous cell carcinoma (SCC) are not fully understood, and the usefulness of topical PDT in the treatment of SCC is still debatable. The most interesting aspect in SCC PDT is perhaps its potential in inducing antitumor immune responses. In this study, cutaneous SCCs were established by UVB irradiation of hairless mice and treated with multiple ALA PDT. Immunohistochemistry assays showed that ALA PDT could induce quick apoptosis, overexpression of TNF and marked increases in DCs, CD4+ and CD8+ cells in tumor interstitium and subcutaneous connective tissues. However, a complete response was only achieved for small SCCs. The clinical value of ALA PDT-induced specific antitumor immune responses in long-term control of SCCs deserves further study.

引用

页码：362 / 363

页数：2

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