Association between reduced expression of hippocampal glucocorticoid receptors and cognitive dysfunction in a rat model of traumatic brain injury due to lateral head acceleration

被引：10
作者：
Gao, Wei [1 ]
Xu, Hongyu [1 ]
Liang, Ming [1 ]
Huang, Jason H. [2 ]
He, Xiaosheng [1 ]
机构：
[1] Fourth Mil Med Univ, Dept Neurosurg, Xijing Hosp, Xian 710032, Peoples R China
[2] Univ Rochester, Dept Neurosurg, Rochester, NY USA
来源：
NEUROSCIENCE LETTERS | 2013年 / 533卷
关键词：
Traumatic brain injury (TBI); Glucocorticoid receptors (GRs); Spatial memory; Hippocampus; Rats; DIFFUSE AXONAL INJURY; TRANSGENIC MICE; MEMORY;
D O I：
10.1016/j.neulet.2012.11.020
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Expression of hippocampal glucocorticoid receptors (GRs) and spatial learning and memory were observed in rat model of diffuse traumatic brain injury (TBI) due to lateral head acceleration with an aim at investigating the relation between GRs expression and cognitive deficits. Immunohistochemical staining, Western blotting, and RT-PCR indicated that down-regulation of GRs expression occurred in the hippocampus among TBI-rats which demonstrated reduced performance of learning and memory in Morris water maze. As the GRs expression bounced up, the cognitive function approached to normal. It is concluded that reduced expression of hippocampal GRs was closely associated with learning and memory deficits in TBI-rats. Hippocampal GRs was involved in the biochemical mechanisms of cognitive deficits after TBI. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：50 / 54
页数：5
相关论文
共 19 条
  • [1] EFFECT OF HIGH-DOSE DEXAMETHASONE ON OUTCOME FROM SEVERE HEAD-INJURY
    DEARDEN, NM
    GIBSON, JS
    MCDOWALL, DG
    GIBSON, RM
    CAMERON, MM
    [J]. JOURNAL OF NEUROSURGERY, 1986, 64 (01) : 81 - 88
  • [2] ANTIGLUCOCORTICOID RU-38486 ATTENUATES RETENTION OF A BEHAVIOR AND DISINHIBITS THE HYPOTHALAMIC-PITUITARY ADRENAL AXIS AT DIFFERENT BRAIN SITES
    DEKLOET, ER
    DEKOCK, S
    SCHILD, V
    VELDHUIS, HD
    [J]. NEUROENDOCRINOLOGY, 1988, 47 (02) : 109 - 115
  • [3] Repeated blockade of mineralocorticoid receptors, but not of glucocorticoid receptors impairs food rewarded spatial learning
    Douma, BRK
    Korte, SM
    Buwalda, B
    la Fleur, SE
    Bohus, B
    Luiten, PGM
    [J]. PSYCHONEUROENDOCRINOLOGY, 1998, 23 (01) : 33 - 44
  • [4] Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer's disease mouse model
    Escribano, Luis
    Simon, Ana-Maria
    Perez-Mediavilla, Alberto
    Salazaf-Colocho, Pablo
    Del Rio, Joaquin
    Frechilla, Diana
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 379 (02) : 406 - 410
  • [5] New rat model for diffuse brain injury using coronal plane angular acceleration
    Fijalkowski, Ronald J.
    Stemper, Brian D.
    Pintar, Frank A.
    Yoganandan, Narayan
    Crowe, Maria J.
    Gennarelli, Thomas A.
    [J]. JOURNAL OF NEUROTRAUMA, 2007, 24 (08) : 1387 - 1398
  • [6] Diffuse axonal injury due to lateral head rotation in a rat model
    He, XS
    Yi, SY
    Zhang, X
    Fei, Z
    Zhang, JN
    Yang, LS
    [J]. JOURNAL OF NEUROSURGERY, 2000, 93 (04) : 626 - 633
  • [7] PERSISTENT WORKING MEMORY DYSFUNCTION FOLLOWING TRAUMATIC BRAIN INJURY: EVIDENCE FOR A TIME-DEPENDENT MECHANISM
    Hoskison, M. M.
    Moore, A. N.
    Hu, B.
    Orsi, S.
    Koboric, N.
    Dash, P. K.
    [J]. NEUROSCIENCE, 2009, 159 (02) : 483 - 491
  • [8] Mineralocorticoid and glucocorticoid receptor expressions in astrocytes and microglia in the gerbil hippocampal CA1 region after ischemic insult
    Hwang, IK
    Yoo, KY
    Nam, YS
    Choi, JH
    Lee, IS
    Kwon, YG
    Kang, TC
    Kim, YS
    Won, MH
    [J]. NEUROSCIENCE RESEARCH, 2006, 54 (04) : 319 - 327
  • [9] Compensatory cortical activation during performance of an attention task by patients with diffuse axonal injury: a functional magnetic resonance imaging study
    Maruishi, M.
    Miyatani, M.
    Nakao, T.
    Muranaka, H.
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2007, 78 (02) : 168 - 173
  • [10] LONG-TERM ANTIDEPRESSANT TREATMENT REDUCES BEHAVIORAL DEFICITS IN TRANSGENIC MICE WITH IMPAIRED GLUCOCORTICOID RECEPTOR FUNCTION
    MONTKOWSKI, A
    BARDEN, N
    WOTJAK, C
    STEC, I
    GANSTER, J
    MEANEY, M
    ENGELMANN, M
    REUL, JMHM
    LANDGRAF, R
    HOLSBOER, F
    [J]. JOURNAL OF NEUROENDOCRINOLOGY, 1995, 7 (11) : 841 - 845
12