Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats

被引：17
|
作者：
Deng, Yu [1 ,3 ]
Tan, Xing [1 ,2 ]
Li, Miao-Ling [4 ]
Wang, Wei-Zhong [1 ,2 ]
Wang, Yang-Kai [1 ,2 ]
机构：
[1] Second Mil Med Univ, Dept Physiol, Shanghai 200433, Peoples R China
[2] Second Mil Med Univ, Inst Polar Med Res Ctr, Shanghai 200433, Peoples R China
[3] Changhai Hosp, Dept Anesthesiol, Shanghai 200433, Peoples R China
[4] Southwest Med Univ, Inst Cardiovasc Med Res, Luzhou 646000, Peoples R China
来源：
NEUROSCIENCE BULLETIN | 2019年 / 35卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Hypertension; Renin-angiotensin system; Gene transfer; Acetylcholine; Sympathetic nerve activity; ACTIVE GLUTAMATERGIC INPUT; BLOOD-PRESSURE REGULATION; ARTERIAL-PRESSURE; BRAIN; RECEPTOR; MECHANISMS; NEURONS; OVEREXPRESSION; ACETYLCHOLINE; BALANCE;
D O I：
10.1007/s12264-018-0298-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The rostral ventrolateral medulla (RVLM) is a key region in cardiovascular regulation. It has been demonstrated that cholinergic synaptic transmission in the RVLM is enhanced in hypertensive rats. Angiotensin-converting enzyme 2 (ACE2) in the brain plays beneficial roles in cardiovascular function in hypertension. The purpose of this study was to determine the effect of ACE2 overexpression in the RVLM on cholinergic synaptic transmission in spontaneously hypertensive rats (SHRs). Four weeks after injecting lentiviral particles containing enhanced green fluorescent protein and ACE2 bilaterally into the RVLM, the blood pressure and heart rate were notably decreased. ACE2 overexpression significantly reduced the concentration of acetylcholine in microdialysis fluid from the RVLM and blunted the decrease in blood pressure evoked by bilateral injection of atropine into the RVLM in SHRs. In conclusion, we suggest that ACE2 overexpression in the RVLM attenuates the enhanced cholinergic synaptic transmission in SHRs.
引用
收藏
页码：67 / 78
页数：12
相关论文
共 50 条
  • [31] Activation of Mineralocorticoid Receptors in the Rostral Ventrolateral Medulla Enhances Sympathetic Activity in Stroke-Prone Spontaneously Hypertensive Rats
    Nakagaki, Toshiaki
    Hirooka, Yoshitaka
    Ito, Koji
    Matsukawa, Ryuji
    Nishihara, Masaaki
    Hoka, Sumio
    Sunagawa, Kenji
    CIRCULATION, 2011, 124 (21)
  • [32] Role of Angiotensin-(1-7) in Rostral Ventrolateral Medulla in Blood Pressure Regulation via Sympathetic Nerve Activity in Wistar-Kyoto and Spontaneous Hypertensive Rats
    Nakagaki, Toshiaki
    Hirooka, Yoshitaka
    Ito, Koji
    Kishi, Takuya
    Hoka, Sumio
    Sunagawa, Kenji
    CLINICAL AND EXPERIMENTAL HYPERTENSION, 2011, 33 (04) : 223 - 230
  • [33] Association of exercise training and angiotensin-converting enzyme 2 activator improves baroreflex sensitivity of spontaneously hypertensive rats
    Lopes, P. R.
    Moreira, M. C. S.
    Marques, S. M.
    Pinto, I. S. J.
    Macedo, L. M.
    Silva, C. C.
    Freiria-Oliveira, A. H.
    Rebelo, A. C. S.
    Reis, A. A. S.
    Rosa, D. A.
    Ferreira-Neto, M. L.
    Castro, C. H.
    Pedrino, G. R.
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2016, 49 (09)
  • [34] Angiotensin-Converting Enzyme Inhibitor Suppresses Activation of Calcineurin in Renovascular Hypertensive Rats
    Hongzhuan Sheng
    Jianhua Zhu
    Xiaohui Wu
    Di Yang
    Jinan Zhang
    Hypertension Research, 2007, 30 : 1247 - 1254
  • [35] Swimming Exercise Changes Hemodynamic Responses Evoked by Blockade of Excitatory Amino Receptors in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats
    Ogihara, Cristiana A.
    Schoorlemmer, Gerhardus H. M.
    Lazari, Maria de Fatima M.
    Giannocco, Gisele
    Lopes, Oswaldo U.
    Colombari, Eduardo
    Sato, Monica A.
    BIOMED RESEARCH INTERNATIONAL, 2014, 2014
  • [36] Cardiovascular protection by angiotensin-converting enzyme 2: a new paradigm
    Ferreira, Anderson J.
    Prada, Jose A. Hernandez
    Ostrov, David A.
    Raizada, Mohan K.
    FUTURE CARDIOLOGY, 2008, 4 (02) : 175 - 182
  • [37] Angiotensin-converting enzyme inhibitor suppresses activation of calcineurin in renovascular hypertensive rats
    Sheng, Hongzhuan
    Zhu, Hanhua
    Wu, Xiaohui
    Yang, Di
    Zhang, Jinan
    HYPERTENSION RESEARCH, 2007, 30 (12) : 1247 - 1254
  • [38] Angiotensin-Converting Enzyme 2: Central Regulator for Cardiovascular Function
    Huijing Xia
    Eric Lazartigues
    Current Hypertension Reports, 2010, 12 : 170 - 175
  • [39] Blockade of Rostral Ventrolateral Medulla (RVLM) Bombesin Receptor Type 1 Decreases Blood Pressure and Sympathetic Activity in Anesthetized Spontaneously Hypertensive Rats
    Pinto, Izabella S.
    Mourao, Aline A.
    da Silva, Elaine F.
    Camargo, Amanda S.
    Marques, Stefanne M.
    Gomes, Karina P.
    Fajemiroye, James O.
    da Silva Reis, Angela A.
    Rebelo, Ana C. S.
    Ferreira-Neto, Marcos L.
    Rosa, Daniel A.
    Freiria-Oliveira, Andre H.
    Castro, Carlos H.
    Colombari, Eduardo
    Colugnati, Diego B.
    Pedrino, Gustavo R.
    FRONTIERS IN PHYSIOLOGY, 2016, 7
  • [40] Gene transfer of angiotensin-converting enzyme 2 in the nucleus tractus solitarius improves baroreceptor heart rate reflex in spontaneously hypertensive rats
    Yamazato, Masanobu
    Ferreira, Anderson J.
    Yamazato, Yoriko
    Diez-Freire, Carlos
    Yuan, Lihui
    Gillies, Robert
    Raizada, Mohan K.
    JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2011, 12 (04) : 456 - 461
12345