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Guanidine-Containing Antifungal Agents against Human-Relevant Fungal Pathogens (2004-2022)-A Review
被引：4
|作者：
Baugh, Simon D. P.
[1
]
机构：
[1] Fox Chase Chem Divers Ctr Inc, 3805 Old Easton Rd, Doylestown, PA 18902 USA
基金：
英国科研创新办公室;
关键词：
antifungal agent;
guanidine;
small molecule;
steroid;
polymer;
metal complex;
sesquiterpene;
natural product;
polypeptide;
ALKALOIDS;
POTENT;
EFFICIENT;
SPONGE;
GUANYLHYDRAZONES;
HYDROCHLORIDE;
DERIVATIVES;
COMPONENTS;
CHEMISTRY;
BIOLOGY;
D O I：
10.3390/jof8101085
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ;
100705 ;
摘要：
The guanidine moiety is typically a highly basic group, and can be found in a wide variety of drugs, such as zanamivir (Relenza) and metformin (Fortamet), as well as in biologically active compounds for numerous disease areas, including central nervous system (CNS) diseases and chemotherapeutics. This review will focus on antifungal agents which contain at least one guanidine group, for the treatment of human-related fungal pathogens, described in the literature between 2004 and 2022. These compounds include small molecules, steroids, polymers, metal complexes, sesquiterpenes, natural products, and polypeptides. It shall be made clear that a diverse range of guanidine-containing derivatives have been published in the literature and have antifungal activity, including efficacy in in vivo experiments.
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页数：31
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