Dopamine-Melanin Colloidal Nanospheres: An Efficient Near-Infrared Photothermal Therapeutic Agent for In Vivo Cancer Therapy

被引：1782

作者：

Liu, Yanlan ^{[1
,2
]}

Ai, Kelong ^{[1
]}

Liu, Jianhua ^{[3
]}

Deng, Mo ^{[4
]}

He, Yangyang ^{[5
]}

Lu, Lehui ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanal Chem, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

[3] Jilin Univ, Hosp 2, Dept Radiol, Changchun 130022, Peoples R China

[4] Jilin Univ, Hosp 2, Dept Clin Lab, Changchun 130022, Peoples R China

[5] Jilin Univ, Hosp 2, Dept Pathol, Changchun 130022, Peoples R China

来源：

ADVANCED MATERIALS | 2013年 / 25卷 / 09期

关键词：

dopamine-melanin; polymers; nanomaterials; biocompatibility; photothermal therapy; PORPHYSOME NANOVESICLES; CONTRAST AGENTS; GOLD NANORODS; ABLATION; CELLS; NANOPARTICLES; LASER; SPECTROSCOPY; HYPERTHERMIA; NANOSHELLS;

D O I：

10.1002/adma.201204683

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new generation of photothermal therapeutic agents based on biopolymer dopamine-melanin colloidal nanospheres is described. Benefitting from their naturally wide distribution in humans, dopamine-melanin colloidal nanospheres exhibit robust biocompatibility and biodegradability, and provide up to 40% photothermal conversion efficiency. After administration, they can efficiently damage tumors at low power density and short irradiation time without damaging healthy tissues. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1353 / 1359

页数：7

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