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Dopamine-Melanin Colloidal Nanospheres: An Efficient Near-Infrared Photothermal Therapeutic Agent for In Vivo Cancer Therapy
被引:1782
作者:
Liu, Yanlan
[1
,2
]
Ai, Kelong
[1
]
Liu, Jianhua
[3
]
Deng, Mo
[4
]
He, Yangyang
[5
]
Lu, Lehui
[1
]
机构:
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanal Chem, Changchun 130022, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
[3] Jilin Univ, Hosp 2, Dept Radiol, Changchun 130022, Peoples R China
[4] Jilin Univ, Hosp 2, Dept Clin Lab, Changchun 130022, Peoples R China
[5] Jilin Univ, Hosp 2, Dept Pathol, Changchun 130022, Peoples R China
关键词:
dopamine-melanin;
polymers;
nanomaterials;
biocompatibility;
photothermal therapy;
PORPHYSOME NANOVESICLES;
CONTRAST AGENTS;
GOLD NANORODS;
ABLATION;
CELLS;
NANOPARTICLES;
LASER;
SPECTROSCOPY;
HYPERTHERMIA;
NANOSHELLS;
D O I:
10.1002/adma.201204683
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
A new generation of photothermal therapeutic agents based on biopolymer dopamine-melanin colloidal nanospheres is described. Benefitting from their naturally wide distribution in humans, dopamine-melanin colloidal nanospheres exhibit robust biocompatibility and biodegradability, and provide up to 40% photothermal conversion efficiency. After administration, they can efficiently damage tumors at low power density and short irradiation time without damaging healthy tissues. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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页码:1353 / 1359
页数:7
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