Dopamine-Melanin Colloidal Nanospheres: An Efficient Near-Infrared Photothermal Therapeutic Agent for In Vivo Cancer Therapy

被引:1782
作者
Liu, Yanlan [1 ,2 ]
Ai, Kelong [1 ]
Liu, Jianhua [3 ]
Deng, Mo [4 ]
He, Yangyang [5 ]
Lu, Lehui [1 ]
机构
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanal Chem, Changchun 130022, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
[3] Jilin Univ, Hosp 2, Dept Radiol, Changchun 130022, Peoples R China
[4] Jilin Univ, Hosp 2, Dept Clin Lab, Changchun 130022, Peoples R China
[5] Jilin Univ, Hosp 2, Dept Pathol, Changchun 130022, Peoples R China
关键词
dopamine-melanin; polymers; nanomaterials; biocompatibility; photothermal therapy; PORPHYSOME NANOVESICLES; CONTRAST AGENTS; GOLD NANORODS; ABLATION; CELLS; NANOPARTICLES; LASER; SPECTROSCOPY; HYPERTHERMIA; NANOSHELLS;
D O I
10.1002/adma.201204683
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A new generation of photothermal therapeutic agents based on biopolymer dopamine-melanin colloidal nanospheres is described. Benefitting from their naturally wide distribution in humans, dopamine-melanin colloidal nanospheres exhibit robust biocompatibility and biodegradability, and provide up to 40% photothermal conversion efficiency. After administration, they can efficiently damage tumors at low power density and short irradiation time without damaging healthy tissues. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:1353 / 1359
页数:7
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