Forkhead box O4 transcription factor in human neoplasms: Cannot afford to lose the novel suppressor

被引：10
|
作者：
Lu, Chenxi [1 ]
Yang, Zhi [2 ]
Jiang, Shuai [3 ]
Yang, Yang [1 ]
Han, Yuehu [4 ]
Lv, Jianjun [2 ]
Li, Tian [2 ]
Chen, Fulin [1 ]
Yu, Yuan [1 ]
机构：
[1] Northwest Univ, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, Fac Life Sci, 229 Taibai North Rd, Xian 710069, Shaanxi, Peoples R China
[2] Fourth Mil Med Univ, Sch Basic Med, Xian, Shaanxi, Peoples R China
[3] Fourth Mil Med Univ, Dept Aerosp Med, Xian, Shaanxi, Peoples R China
[4] Fourth Mil Med Univ, Xijing Hosp, Dept Cardiovasc Surg, Xian, Shaanxi, Peoples R China
来源：
JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 06期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
cancer; clinical application; FOXO4; progression; ROUND-CELL SARCOMA; DOWN-REGULATION; GASTRIC-CANCER; CLINICOPATHOLOGICAL FEATURES; MYELOID-LEUKEMIA; TUMOR-METASTASIS; UP-REGULATION; GENE FUSION; FACTOR AFX; FOXO4;
D O I：
10.1002/jcp.27853
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Forkhead box O4 (FOXO4), a member of FOXO family, has been highlighted as an essential transcriptional regulator in many diverse carcinomas. Accumulated studies have demonstrated that FOXO4 is downregulated and associated with tumorigenesis, invasiveness, and metastasis of most human cancer. FOXO4 alteration is also closely linked to the prognosis of various types of cancer. The aim of this review is to comprehensively present the clinical and pathological significance of FOXO4 in human cancer. Additionally, the potential clinical applications of future FOXO4 research are discussed. Collectively, the information reviewed here should increase the potential of FOXO4 as a therapeutic target for cancer.
引用
收藏
页码：8647 / 8658
页数：12
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