In Vitro Bactericidal Activity of Trimethoprim-Sulfamethoxazole/Colistin Combination Against Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates

被引：14
作者：
Su, Jiachun [1 ,2 ]
Li, Dan [1 ,2 ]
Guo, Qinglan [1 ,2 ]
Guo, Yan [1 ,2 ]
Zheng, Yonggui [1 ,2 ]
Xu, Xiaogang [1 ,2 ,3 ]
机构：
[1] Fudan Univ, Huashan Hosp, Inst Antibiot, 12 Middle Wulumuqi Rd, Shanghai 200040, Peoples R China
[2] Natl Hlth & Family Planning Commiss, Key Lab Clin Pharmacol Antibiot, Shanghai, Peoples R China
[3] Fudan Univ, Huashan Hosp, Natl Clin Res Ctr Aging & Med, Shanghai, Peoples R China
来源：
MICROBIAL DRUG RESISTANCE | 2019年 / 25卷 / 02期
关键词：
carbapenem-resistant Klebsiella pneumoniae; trimethoprim-sulfamethoxazole; colistin; bactericidal activity; COLISTIN; THERAPY;
D O I：
10.1089/mdr.2018.0085
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Carbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged as a formidable health challenge in recent years owing to the shortage of effective antibiotics. Colistin is the last and sometimes the only therapeutic option for CRKP infections. Unfortunately, resistance to colistin monotherapy is likely to develop. CRKP in China reportedly exhibit low rates of resistance to trimethoprim-sulfamethoxazole. The aim of this study was to evaluate the in vitro efficacy of trimethoprim-sulfamethoxazole in combination with colistin against four CRKP clinical isolates. The trimethoprim-sulfamethoxazole/colistin combination rapidly killed all four of the tested isolates after 2 h up to 24 h. Trimethoprim-sulfamethoxazole is one of the few remaining antimicrobials with some activity against CRKP. In particular, combined with colistin, trimethoprim-sulfamethoxazole might be promising for the treatment of CRKP infections.
引用
收藏
页码：152 / 156
页数：5
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