Cortical LTP: A Synaptic Model for Chronic Pain

被引：12
|
作者：
Zhuo, Min [1 ]
机构：
[1] Univ Toronto, Ctr Study Pain, Fac Med, Dept Physiol, Med Sci Bldg, Toronto, ON, Canada
来源：
ADVANCES IN PAIN RESEARCH: MECHANISMS AND MODULATION OF CHRONIC PAIN | 2018年 / 1099卷
关键词：
Anterior cingulate cortex; Insular cortex; Long-term potentiation; NMDA; AC1; ANTERIOR CINGULATE CORTEX; LONG-TERM POTENTIATION; NEUROPATHIC PAIN; ADENYLYL-CYCLASE; INSULAR CORTEX; PLASTICITY; RESPONSES; ANXIETY;
D O I：
10.1007/978-981-13-1756-9_13
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cumulative evidence indicates that cortical synapses not only play important roles in pain perception and related emotional functions but also undergo long-term potentiation (LTP) and contribute to chronic pain. LTP is found at two key cortical regions such as the anterior cingulate cortex (ACC) and insular cortex (IC), and inhibition of cortical LTP produces analgesic effects as well as anxiolytic effects. In this chapter, I will summarize our work on ACC and IC and provide evidence for calcium-stimulated AC1 as a key molecule for cortical LTP and chronic pain.
引用
收藏
页码：147 / 155
页数：9
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