Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin

被引：34

作者：

Ellis, E

Wagner, M

Lammert, F

Nemeth, A

Gumhold, J

Strassburg, CP

Kylander, C

Katsika, D

Trauner, M

Einarsson, C

Marschall, HU ^{[1
]}

机构：

[1] Karolinska Univ, Huddinge Hosp K63, Dept Med, Div Gastroenterol Hepatol,Karolinska Inst, S-14186 Huddinge, Sweden

[2] Med Univ Graz, Dept Med, Div Gastroenterol & Hepatol, Graz, Austria

[3] Univ Bonn, Univ Hosp Bonn, Dept Internal Med 1, D-5300 Bonn, Germany

[4] Karolinska Univ, Huddinge Hosp, Dept Pediat, Karolinska Inst, S-14186 Huddinge, Sweden

[5] Karolinska Univ, Huddinge Hosp, Dept Surg, Karolinska Inst, S-14186 Huddinge, Sweden

[6] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-3000 Hannover, Germany

来源：

JOURNAL OF HEPATOLOGY | 2006年 / 44卷 / 01期

关键词：

Gilbert; jaundice; glucuronosyltransferase; cultured human hepatocytes;

D O I：

10.1016/j.jhep.2005.09.011

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We report two patients with uncommon Gilbert's syndrome with severe unconjugated hyperbilirubinemia which was reduced from 200 to 60-90 mu mol/L by long-term administration of rifampicin. Hepatic induction of bilirubinglucuronosyltransferase was suggested by increased relative amounts of conjugated serum bilirubin. This molecular mechanism was confirmed in primary cultures of human hepatocytes. (c) 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

引用

页码：243 / 245

页数：3

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