Objectives: The aim of this study was to compare the 2-year clinical performance of three restorative systems, which included a novel low-shrinkage composite and two bonding strategies. Methods: After signing the appropriate informed consent, 25 patients received three Class I (occlusal) or Class II restorations performed with one of three restorative systems: Filtek Silorane Restorative System; Adper Scotchbond 1 XT (a 2-step total-etch adhesive) with Filtek Z250; and Adper Scotchbond SE (a 2-step self-etch adhesive) with Filtek Z250. All materials were applied following the manufacturer's instructions. Two independent observers evaluated the restorations at baseline, after 1 and 2 years, according to the USPHS modified criteria. Kruskal-Wallis and Mann Whitney U tests were computed to compare the behavior of the restorative systems; Friedman and Wilcoxon tests were used to analyze the intra-system data (p<0.05). Results: The three restorative systems performed statistically similar at 2 years. Intra-system comparisons between baseline and 2 years showed worse marginal adaptation scores for all the restorative systems. Marginal staining and surface roughness parameters also recorded higher values than at baseline for Adper Scotchbond SE + Filtek Z250. Conclusions: Although the clinical performance of Filtek Silorane Restorative System was demeed acceptable after 2 years, this study did not find any advantage of the silorane-based composite over the methacrylate-based composite, as marginal adaptation did not improve with the low-shrinkage resin.