Associations between TAB2 gene polymorphisms and dilated cardiomyopathy in a Chinese population

被引：2
|
作者：
Shen, Can [1 ,2 ]
Zhong, Yue [1 ,2 ]
Huang, Xingming [2 ,3 ]
Wang, Yanyun [2 ]
Peng, Ying [1 ]
Li, Kai [1 ,2 ]
Zhou, Bin [2 ]
Zhang, Lin [2 ]
Rao, Li [1 ]
机构：
[1] Sichuan Univ, Dept Cardiol, West China Hosp, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Child, Lab Mol Translat Med,Ctr Translat Med, Minist Educ,West China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China
[3] Sichuan Univ, Dept Pathol, West China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China
来源：
BIOMARKERS IN MEDICINE | 2020年 / 14卷 / 06期
基金：
中国国家自然科学基金;
关键词：
dilated cardiomyopathy; polymorphism; survival analysis; TAB2; NF-KAPPA-B; CONGENITAL HEART-DEFECTS; RHEUMATOID-ARTHRITIS; KINASE TAK1; TNF-ALPHA; CLASSIFICATION; ACTIVATION; CARDIOLOGY; FAILURE; MICRODELETION;
D O I：
10.2217/bmm-2019-0384
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: The present study aimed to investigate the role of TAB2 gene polymorphisms in dilated cardiomyopathy (DCM) susceptibility and prognosis in a Chinese population. Materials & methods: A total of 343 DCM patients and 451 controls were enrolled and had their blood genotyped. Survival analysis was evaluated with Kaplan-Meier curves and Cox regression analysis. Results: G carriers (AG/GG) and AG genotype of rs237028 had a higher DCM susceptibility as well as a worse DCM prognosis. Additionally, C carriers (CT/CC) of rs652921 and G carriers (TG/GG) of rs521845 had a higher DCM risk and CC homozygote of rs652921 had a worse DCM prognosis. These associations were still significant after adjustment for the Bonferroni correction. Conclusion: TAB2 gene polymorphisms were associated with DCM susceptibility and prognosis in the Chinese population.
引用
收藏
页码：441 / 450
页数：10
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