The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease

被引：239
作者：
Bai, Peter [1 ,2 ]
Canto, Carles [3 ]
机构：
[1] Univ Debrecen, Med & Hlth Sci Ctr, Dept Med Chem, H-4032 Debrecen, Hungary
[2] Hungarian Acad Sci, Cell Biol & Signaling Res Grp, H-4032 Debrecen, Hungary
[3] Nestle Inst Hlth Sci, CH-1015 Lausanne, Switzerland
来源：
CELL METABOLISM | 2012年 / 16卷 / 03期
关键词：
POLY(ADP-RIBOSE) POLYMERASE 1; ADIPOCYTE FUNCTION; DIFFERENTIATION; EXPRESSION; NAD(+); GENE;
D O I：
10.1016/j.cmet.2012.06.016
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
While originally described as DNA damage repair agents, recent data suggest a role for poly(ADP-ribose) polymerase (PARP) enzymes in metabolic regulation by influencing mitochondrial function and oxidative metabolism. Here we review how PARP activity has a major metabolic impact and the role of PARP-1 and PARP-2 in diverse metabolic complications.
引用
收藏
页码：290 / 295
页数：6
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