Biologically Responsive Polymeric Nanoparticles for Drug Delivery

被引：183
作者：
Colson, Yolonda L. [1 ]
Grinstaff, Mark W. [2 ,3 ]
机构：
[1] Brigham & Womens Hosp, Dept Surg, Div Thorac Surg, Boston, MA 02215 USA
[2] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA
[3] Boston Univ, Dept Chem, Boston, MA 02215 USA
来源：
ADVANCED MATERIALS | 2012年 / 24卷 / 28期
基金：
美国国家科学基金会;
关键词：
responsive system; triggered drug delivery; nanoparticles; pH; oxidation; POLY(BETA-AMINO ESTER) NANOPARTICLES; TUMOR-TARGETED DELIVERY; PH-SENSITIVE SYSTEM; LOADED EXPANSILE NANOPARTICLES; IN-VIVO; HYDROPHOBIC DRUGS; LYMPH-NODES; PACLITAXEL; PARTICLES; DEGRADATION;
D O I：
10.1002/adma.201200420
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Responsive nanoparticles that release their drug cargo in accordance with a change in pH or oxidative stress are of significant clinical interest as this approach offers the opportunity to link drug delivery to a specific location or disease state. This research news article reviews the current state of this field by examining a series of published articles that highlight the novelty and benefits of using responsive polymeric particles to achieve functionally-targeted drug delivery.
引用
收藏
页码：3878 / 3886
页数：9
相关论文
共 44 条
[11]   Nanoparticle therapeutics: an emerging treatment modality for cancer [J].
Davis, Mark E. ;
Chen, Zhuo ;
Shin, Dong M. .
NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (09) :771-782
[12]   Oral bioavailability of a poorly water soluble HIV-1 protease inhibitor incorporated into pH-sensitive particles:: effect of the particle size and nutritional state [J].
De Jaeghere, F ;
Allémann, E ;
Kubel, F ;
Galli, B ;
Cozens, R ;
Doelker, E ;
Gurny, R .
JOURNAL OF CONTROLLED RELEASE, 2000, 68 (02) :291-298
[13]   Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model [J].
Devalapally, Harikrishna ;
Shenoy, Dinesh ;
Little, Steven ;
Langer, Robert ;
Amiji, Mansoor .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2007, 59 (04) :477-484
[14]   Development of acrylic-based copolymers for oral insulin delivery [J].
Foss, AC ;
Goto, T ;
Morishita, M ;
Peppas, NA .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2004, 57 (02) :163-169
[15]   Expansile Nanoparticles: Synthesis, Characterization, and in Vivo Efficacy of an Acid-Responsive Polymeric Drug Delivery System [J].
Griset, Aaron P. ;
Walpole, Joseph ;
Liu, Rong ;
Gaffey, Ann ;
Colson, Yolonda L. ;
Grinstaff, Mark W. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (07) :2469-+
[16]   Liposomes in ultrasonic drug and gene delivery [J].
Huang, Shao-Ling .
ADVANCED DRUG DELIVERY REVIEWS, 2008, 60 (10) :1167-1176
[17]   Polymer genomics: An insight into pharmacology and toxicology of nanomedicines [J].
Kabanov, Alexander V. .
ADVANCED DRUG DELIVERY REVIEWS, 2006, 58 (15) :1597-1621
[18]   Nanoparticle Migration and Delivery of Paclitaxel to Regional Lymph Nodes in a Large Animal Model [J].
Khullar, Onkar V. ;
Griset, Aaron P. ;
Gibbs-Strauss, Summer L. ;
Chirieac, Lucian R. ;
Zubris, Kimberly A. V. ;
Frangioni, John V. ;
Grinstaff, Mark W. ;
Colson, Yolonda L. .
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2012, 214 (03) :328-337
[19]   PHARMACOKINETICS OF A NOVEL HIV-1 PROTEASE INHIBITOR INCORPORATED INTO BIODEGRADABLE OR ENTERIC NANOPARTICLES FOLLOWING INTRAVENOUS AND ORAL-ADMINISTRATION TO MICE [J].
LEROUX, JC ;
COZENS, R ;
ROESEL, JL ;
GALLI, B ;
KUBEL, F ;
DOELKER, E ;
GURNY, R .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1995, 84 (12) :1387-1391
[20]   Paclitaxel-Loaded Expansile Nanoparticles Delay Local Recurrence in a Heterotopic Murine Non-Small Cell Lung Cancer Model [J].
Liu, Rong ;
Khullar, Onkar V. ;
Griset, Aaron P. ;
Wade, Jacqueline E. ;
Zubris, Kimberly Ann V. ;
Grinstaff, Mark W. ;
Colson, Yolonda L. .
ANNALS OF THORACIC SURGERY, 2011, 91 (04) :1077-1083
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