Biologically Responsive Polymeric Nanoparticles for Drug Delivery

被引：183

作者：

Colson, Yolonda L. ^{[1
]}

Grinstaff, Mark W. ^{[2
,3
]}

机构：

[1] Brigham & Womens Hosp, Dept Surg, Div Thorac Surg, Boston, MA 02215 USA

[2] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA

[3] Boston Univ, Dept Chem, Boston, MA 02215 USA

来源：

ADVANCED MATERIALS | 2012年 / 24卷 / 28期

基金：

美国国家科学基金会;

关键词：

responsive system; triggered drug delivery; nanoparticles; pH; oxidation; POLY(BETA-AMINO ESTER) NANOPARTICLES; TUMOR-TARGETED DELIVERY; PH-SENSITIVE SYSTEM; LOADED EXPANSILE NANOPARTICLES; IN-VIVO; HYDROPHOBIC DRUGS; LYMPH-NODES; PACLITAXEL; PARTICLES; DEGRADATION;

D O I：

10.1002/adma.201200420

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Responsive nanoparticles that release their drug cargo in accordance with a change in pH or oxidative stress are of significant clinical interest as this approach offers the opportunity to link drug delivery to a specific location or disease state. This research news article reviews the current state of this field by examining a series of published articles that highlight the novelty and benefits of using responsive polymeric particles to achieve functionally-targeted drug delivery.

引用

页码：3878 / 3886

页数：9

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