Synthesis of titanium oxide thin films containing antibacterial silver nanoparticles by a reactive magnetron co-sputtering system for application in biomedical implants

被引：34

作者：

Song, Doo-Hoon ^{[1
]}

Uhm, Soo-Hyuk ^{[1
,2
]}

Kim, Si-Eun ^{[1
,2
]}

Kwon, Jae-Sung ^{[1
]}

Han, Jeon-Geon ^{[3
]}

Kim, Kyoung-Nam ^{[1
,2
]}

机构：

[1] Yonsei Univ, Coll Dent, Res Ctr Orofacial Hard Tissue Regenerat, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Dent, Dept & Res Inst Dent Biomat & Bioengn, Seoul 120752, South Korea

[3] Sungkyunkwan Univ, Ctr Adv Plasma Surface Technol, Suwon 440746, South Korea

来源：

MATERIALS RESEARCH BULLETIN | 2012年 / 47卷 / 10期

关键词：

Composites; Thin films; Sputtering; Electron microscopy; Photoelectron spectroscopy; Surface properties; AG; INFECTIONS; ROUTE;

D O I：

10.1016/j.materresbull.2012.04.085

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Titanium oxide thin films containing silver (Ag) nanoparticles were synthesized on commercially pure titanium (cp-Ti) substrates using a reactive magnetron co-sputtering method. The goal was to maximize bactericidal activity along with sustained biocompatibility. Furthermore, this study examined the correlation between Ag nanoparticle dispersion in the films and the antibacterial efficacy of the Ag ions released from the films. The results showed that there might be two factors affecting the inhibition of bacterial attachment to the surface of the specimens: surface morphology and Ag ion release. MU assay results demonstrated that there was no cytotoxicity on fibroblast cells in any group. Overall, the magnetron sputtered Ag nanoparticle-containing titanium oxide coatings in this study can be used as an efficient antibacterial layer with sustained biocompatibility. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2994 / 2998

页数：5

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