Comparative genomic analysis of eutherian interferon-γ-inducible GTPases

被引：8
作者：
Premzl, Marko [1 ]
机构：
[1] Ctr Anim Reprod, Lab Genom, Zagreb 10000, Croatia
来源：
FUNCTIONAL & INTEGRATIVE GENOMICS | 2012年 / 12卷 / 04期
关键词：
Comparative genomic analysis; Gene annotations; Interferon-gamma-inducible GTPases; Molecular evolution; Phylogenetic analysis; IFN-GAMMA; INTRACELLULAR PATHOGENS; RESISTANCE GTPASES; HOST-RESISTANCE; IRG PROTEINS; LRG-47; MOUSE; GENE; IDENTIFICATION; FAMILY;
D O I：
10.1007/s10142-012-0291-2
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The interferon-gamma-inducible GTPases, IFGGs, are intracellular proteins involved in immune response against pathogens. A comprehensive comparative genomic review and analysis of eutherian IFGGs was carried out using public genomic sequences. The 64 eutherian IFGG genes were examined in detail and annotated. The eutherian IFGG promoter types were first catalogued followed by a phylogenetic analysis of eutherian IFGGs, which described five major IFGG clusters. The patterns of differential gene expansions and protein regions that may regulate IFGG catalytic features suggested a new classification of eutherian IFGGs. This mini-review has also provided new tests of reliability of public genomic sequences as well as tests of protein molecular evolution.
引用
收藏
页码：599 / 607
页数：9
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