Osteonecrosis in patients with systemic lupus erythematosus develops very early after starting high dose corticosteroid treatment

被引：133
作者：
Oinuma, K
Harada, Y
Nawata, Y
Takabayashi, K
Abe, I
Kamikawa, K
Moriya, H
机构：
[1] Chiba Univ, Sch Med, Dept Orthopaed Surg, Chiba 280, Japan
[2] Chiba Univ, Sch Med, Dept Internal Med 2, Chiba 280, Japan
来源：
ANNALS OF THE RHEUMATIC DISEASES | 2001年 / 60卷 / 12期
关键词：
D O I：
10.1136/ard.60.12.1145
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objectives-To investigate the actual time of onset of osteonecrosis (ON) after high dose corticosteroid treatment in systemic lupus erythematosus (SLE). Methods-72 patients with active SLE, who received high dose corticosteroid for the first time, for the development of ON at hips and knees were monitored by magnetic resonance imaging for at least 12 months. Results-ON lesions were detected in 32/72 patients (44%) between one and five months (3.1 months on average) after starting high dose corticosteroid treatment. No osteonecrotic lesion was newly, detected from the sixth month of treatment until the end of the follow up period. Conclusion-The findings suggested that the actual time of onset of ON in SLE is within the first month of high dose corticosteroid treatment.
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收藏
页码：1145 / 1148
页数：4
相关论文
共 20 条
[1]   DERIVATION OF THE SLEDAI - A DISEASE-ACTIVITY INDEX FOR LUPUS PATIENTS [J].
BOMBARDIER, C ;
GLADMAN, DD ;
UROWITZ, MB ;
CARON, D ;
CHANG, CH .
ARTHRITIS AND RHEUMATISM, 1992, 35 (06) :630-640
[2]   RADIOGRAPHICALLY NEGATIVE AVASCULAR NECROSIS - DETECTION WITH MR IMAGING [J].
COLEMAN, BG ;
KRESSEL, HY ;
DALINKA, MK ;
SCHEIBLER, ML ;
BURK, DL ;
COHEN, EK .
RADIOLOGY, 1988, 168 (02) :525-528
[3]  
Cozen L, 1998, J RHEUMATOL, V25, P188
[4]  
Houssiau FA, 1998, BRIT J RHEUMATOL, V37, P448
[5]  
Hurley R M, 1974, Can Med Assoc J, V111, P781
[6]   Evaluating systemic lupus erythematosus disease activity using molecular markers of hemostasis [J].
Inoh, M ;
Tokuda, M ;
Kiuchi, H ;
Kurata, N ;
Takahara, J .
ARTHRITIS AND RHEUMATISM, 1996, 39 (02) :287-291
[7]   APPARENT AVASCULAR NECROSIS OF THE HIP - APPEARANCE AND SPONTANEOUS RESOLUTION OF MR FINDINGS IN RENAL-ALLOGRAFT RECIPIENTS [J].
KOPECKY, KK ;
BRAUNSTEIN, EM ;
BRANDT, KD ;
FILO, RS ;
LEAPMAN, SB ;
CAPELLO, WN ;
KLATTE, EC .
RADIOLOGY, 1991, 179 (02) :523-527
[8]   AVASCULAR NECROSIS OF THE FEMORAL-HEAD - HIGH-FIELD-STRENGTH MR IMAGING WITH HISTOLOGIC CORRELATION [J].
LANG, P ;
JERGESEN, HE ;
MOSELEY, ME ;
BLOCK, JE ;
CHAFETZ, NI ;
GENANT, HK .
RADIOLOGY, 1988, 169 (02) :517-524
[9]   SEGMENTAL PATTERNS OF AVASCULAR NECROSIS OF THE FEMORAL HEADS - EARLY DETECTION WITH MR IMAGING [J].
MARKISZ, JA ;
KNOWLES, RJR ;
ALTCHEK, DW ;
SCHNEIDER, R ;
WHALEN, JP ;
CAHILL, PT .
RADIOLOGY, 1987, 162 (03) :717-720
[10]   AVASCULAR OSTEONECROSIS IN PATIENTS WITH SLE - RELATION TO CORTICOSTEROID-THERAPY AND ANTICARDIOLIPIN ANTIBODIES [J].
MIGLIARESI, S ;
PICILLO, U ;
AMBROSONE, L ;
DIPALMA, G ;
MALLOZZI, M ;
TESONE, ER ;
TIRRI, G .
LUPUS, 1994, 3 (01) :37-41
12