MULTICOMPONENT SYNTHESIS OF 1,2,3-TRIAZOL-4-YL-METHYLTHIO-3-ARYLQUINAZOLIN-4(3H)-ONE DERIVATIVES

被引：4

作者：

Koohshari, Majid

Dabiri, Minoo ^{[1
]}

Salehi, Peyman ^{[2
]}

Bahramnejad, Mahboobeh

机构：

[1] Shahid Beheshti Univ, Dept Chem, Fac Sci, GC, Tehran, Iran

[2] Shahid Beheshti Univ, Dept Phytochem, Med Plants & Drugs Res Inst, Tehran, Iran

来源：

SYNTHETIC COMMUNICATIONS | 2012年 / 42卷 / 16期

关键词：

Azide; click chemistry; propargyl bromide; quinazolinone; 1,2,3-triazole; ANTIMALARIAL ACTIVITY; SOLID-PHASE; QUINAZOLINE; 2-STYRYLQUINAZOLIN-4(3H)-ONES; CYCLOADDITION;

D O I：

10.1080/00397911.2011.558968

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel, one-pot, three-component reaction for the synthesis of novel 1,2,3-triazol-4-yl-methylthio-3-arylquinazolin-4(3H)-one derivatives using the Huisgen 1,3-dipolar cycloaddition reaction of organic azides and in situ-prepared terminal alkynes in good to excellent yields is reported.

引用

页码：2415 / 2422

页数：8

共 36 条

[31] Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(I)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides [J].