MULTICOMPONENT SYNTHESIS OF 1,2,3-TRIAZOL-4-YL-METHYLTHIO-3-ARYLQUINAZOLIN-4(3H)-ONE DERIVATIVES

被引：4

作者：

Koohshari, Majid

Dabiri, Minoo ^{[1
]}

Salehi, Peyman ^{[2
]}

Bahramnejad, Mahboobeh

机构：

[1] Shahid Beheshti Univ, Dept Chem, Fac Sci, GC, Tehran, Iran

[2] Shahid Beheshti Univ, Dept Phytochem, Med Plants & Drugs Res Inst, Tehran, Iran

来源：

SYNTHETIC COMMUNICATIONS | 2012年 / 42卷 / 16期

关键词：

Azide; click chemistry; propargyl bromide; quinazolinone; 1,2,3-triazole; ANTIMALARIAL ACTIVITY; SOLID-PHASE; QUINAZOLINE; 2-STYRYLQUINAZOLIN-4(3H)-ONES; CYCLOADDITION;

D O I：

10.1080/00397911.2011.558968

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel, one-pot, three-component reaction for the synthesis of novel 1,2,3-triazol-4-yl-methylthio-3-arylquinazolin-4(3H)-one derivatives using the Huisgen 1,3-dipolar cycloaddition reaction of organic azides and in situ-prepared terminal alkynes in good to excellent yields is reported.

引用

收藏

页码：2415 / 2422

页数：8

相关论文

共 36 条

[1] Parallel Microwave Synthesis of 2-Styrylquinazolin-4(3H)-ones in a High-Throughput, Platform Using HPLC/GC Vials as Reaction Vessels [J].

Baghbanzadeh, Mostafa ;

Molnar, Maja ;

Damm, Markus ;

Reidlinger, Claudia ;

Dabiri, Minoo ;

Kappe, C. Oliver .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2009, 11 (04) :676-684

[2]

Bruse K., 2010, ORGANIC AZIDES SYNTH, P1

[3] Synthesis of Diheterocyclic Compounds Based on Triazolyl Methoxy Phenylquinazolines via a One-Pot Four-Component-Click Reaction [J].

Dabiri, Minoo ;

Salehi, Peyman ;

Bahramnejad, Mahboobeh ;

Sherafat, Fatemeh .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2010, 12 (05) :638-642

[4] Microwave-assisted synthesis in water as solvent [J].

Dallinger, Doris ;

Kappe, C. Oliver .

CHEMICAL REVIEWS, 2007, 107 (06) :2563-2591

[5] Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: Selective inhibitors of Aurora B kinase with potent anti-tumor activity [J].

Foote, Kevin M. ;

Mortlock, Andrew A. ;

Heron, Nicola M. ;

Jung, Frederic H. ;

Hill, George B. ;

Pasquet, Georges ;

Brady, Madeleine C. ;

Green, Stephen ;

Heaton, Simon P. ;

Kearney, Sarah ;

Keen, Nicholas J. ;

Odedra, Rajesh ;

Wedge, Stephen R. ;

Wilkinson, Robert W. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (06) :1904-1909

[6]

Fowler K.W., 2005, Patents, Patent No. [US16778, 16778]

[7]

Fowler K. W., 2005, Patent No. 2005113556

[8] Tautomerism of guanidines studied by 15N NMR: 2-hydrazono-3-phenylquinazolin-4(3H)-ones and related compounds [J].

Ghiviriga, Ion ;

El-Gendy, Bahaa El-Dien M. ;

Steel, Peter J. ;

Katritzky, Alan R. .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2009, 7 (19) :4110-4119

[9] Highly active copper-catalysts for azide-alkyne cycloaddition [J].

Gonda, Zsombor ;

Novak, Zoltan .

DALTON TRANSACTIONS, 2010, 39 (03) :726-729

[10] γ-Methyl-substituted-γ-butyrolactones:: solid-phase synthesis employing a cyclisation-cleavage strategy [J].

Gouault, N ;

Cupif, JF ;

Sauleau, A ;

David, M .

TETRAHEDRON LETTERS, 2000, 41 (38) :7293-7297

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