The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties

被引：141

作者：

Tan, Suet-Mien ^{[1
]}

机构：

[1] Nanyang Technol Univ, Div Mol Genet & Cell Biol, Sch Biol Sci, Singapore 637551, Singapore

来源：

BIOSCIENCE REPORTS | 2012年 / 32卷 / 03期

关键词：

cell adhesion; integrin; leucocyte; migration; structure; FUNCTION-ASSOCIATED ANTIGEN-1; SRC-FAMILY KINASES; COMPLEMENT RECEPTOR TYPE-3; T-CELL-ACTIVATION; INTERCELLULAR-ADHESION MOLECULE-1; ALPHA(L)BETA(2) HYBRID DOMAIN; INSIDE-OUT ACTIVATION; I-DOMAIN; CRYSTAL-STRUCTURE; TYROSINE KINASE;

D O I：

10.1042/BSR20110101

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leucocytes are highly motile cells. Their ability to migrate into tissues and organs is dependent on cell adhesion molecules. The integrins are a family of heterodimeric transmembrane cell adhesion molecules that are also signalling receptors. They are involved in many biological processes, including the development of metazoans, immunity, haemostasis, wound healing and cell survival, proliferation and differentiation. The leucocyte-restricted beta 2 integrins comprise four members, namely alpha L beta 2, alpha M beta 2, alpha X beta 2 and alpha D beta 2, which are required for a functional immune system. In this paper, the structure, functional regulation and signalling properties of these integrins are reviewed.

引用

页码：241 / 269

页数：29

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