The control of histone gene expression

被引:47
作者
Rattray, Alexander M. J. [1 ]
Mueller, Berndt [1 ]
机构
[1] Univ Aberdeen, Sch Med Sci, Aberdeen AB25 2ZD, Scotland
基金
英国生物技术与生命科学研究理事会;
关键词
cell cycle; DNA replication; histone gene expression; RNA degradation; RNA processing; translation; LOOP BINDING-PROTEIN; CELL-CYCLE PROGRESSION; POLYADENYLATION FACTOR CPSF-73; MESSENGER-RNA DECAY; 3' END FORMATION; S-PHASE; U7; SNRNP; CAENORHABDITIS-ELEGANS; UPF1; PHOSPHORYLATION; TRIGGERS DEGRADATION;
D O I
10.1042/BST20120065
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Histone proteins are essential for the packaging of DNA into chromosomes. Histone gene expression is cell-cycle-regulated and coupled to DNA replication. Control of histone gene expression occurs at the transcriptional and post-transcriptional level and ensures that a fine balance between histone abundance and DNA replication is maintained for the correct packaging of newly replicated DNA into chromosomes. In the present paper, we review histone gene expression, highlighting the control mechanisms and key molecules involved in this process.
引用
收藏
页码:880 / 885
页数:6
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