Liquid Biopsies in Cancer Diagnosis, Monitoring, and Prognosis

被引：419

作者：

De Rubis, Gabriele ^{[1
]}

Krishnan, Sabna Rajeev ^{[1
]}

Bebawy, Mary ^{[1
]}

机构：

[1] Univ Technol Sydney Australia, Grad Sch Hlth, Discipline Pharm, POB 123, Broadway, NSW 2007, Australia

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2019年 / 40卷 / 03期

关键词：

CIRCULATING-TUMOR-CELLS; PRIMARY BREAST-CANCER; EXTRACELLULAR VESICLES; COLORECTAL-CANCER; SERUM EXOSOMES; CLINICAL-APPLICATIONS; MICROFLUIDIC DEVICE; SENSITIVE DETECTION; MUTATIONAL ANALYSIS; MICRORNA SIGNATURE;

D O I：

10.1016/j.tips.2019.01.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Liquid biopsies, comprising the noninvasive analysis of circulating tumor derived material (the 'tumor circulome'), represent an innovative tool in precision oncology to overcome current limitations associated with tissue biopsies. Within the tumor circulome, circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) are the only components the clinical application of which is approved by the US Food and Drug Administration (FDA). Extracellular vesicles (EVs), circulating tumor RNA (ctRNA), and tumor-educated platelets (TEPs) are relatively new tumor circulome constituents with promising potential at each stage of cancer management. Here, we discuss the clinical applications of each element of the tumor circulome and the prevailing factors that currently limit their implementation in clinical practice. We also detail the most recent technological developments in the field, which demonstrate potential in mproving the clinical value of liquid biopsies.

引用

页码：172 / 186

页数：15

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