Loss of Runt-Related Transcription Factor 3 Expression Associated with Human Hepatocellular Carcinoma Progression and Prognosis

被引：0
|
作者：
Li, Jianguo [1 ]
Jiang, Xiaojie [2 ]
机构：
[1] Fujian Med Univ, Zhangzhou Affiliated Hosp, Dept Hepatobiliary Surg, Zhangzhou, Peoples R China
[2] Putian Univ, Putian Affiliated Hosp, Dept Surg Oncol, Putian, Peoples R China
来源：
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2011年 / 12卷 / 09期
关键词：
Runt-related transcription factor 3; HCC; fluorescent quantitative PCR; gene expression; TUMOR PROGRESSION; GENE; GROWTH; CANCER; CELLS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: This study aimed to evaluate the expression level of runt-related transcription factor 3 (RUNX3) in human primary hepatocellular carcinomas (HCCs) and its relationship with the clinic pathological features. Methods: RUNX3 expression was analyzed by real-time fluorescent quantitative PCR, immunohistochemistry and Western blotting in HCC cells and tissues. Results: RUNX3 mRNA and protein expression was decreased in HCC tissues compared with the adjacent normal tissues (P<0.001), mRNA frequently being down-regulated in HCC cell lines (66.7%, 4/6). Low expression of RUNX3 showed a significant correlation with cirrhosis (P=0.028), histologic type (P=0.000) and lymph node metastasis (P=0.004). Conclusion: RUNX3 expression is deleted or decreased in HCCs and cell lines, in association with progression and prognosis.
引用
收藏
页码：2285 / 2290
页数：6
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