SH2 domains, interaction modules and cellular wiring

被引:303
作者
Pawson, T
Gish, GD
Nash, P
机构
[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Programme Mol Biol & Canc, Toronto, ON M5G 1X5, Canada
[2] Univ Toronto, Dept Med Genet & Microbiol, Toronto, ON M5S 1A8, Canada
基金
加拿大健康研究院;
关键词
D O I
10.1016/S0962-8924(01)02154-7
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
SH2 domains serve as the prototype for a growing family of protein-interaction modules, characteristic of polypeptides involved in transmitting signals from external and internal cues. The specific interactions of proteins with one another, and with other cellular components such as phospholipids and nucleic acids, provide a very general device to organize cellular behavior. We discuss the idea that rewiring of the cell's interaction network by pathogenic microorganisms and mutant cellular proteins contributes to dysregulation of cell signaling and thus to disease.
引用
收藏
页码:504 / 511
页数:8
相关论文
共 82 条
[51]  
Pawson T, 2000, GENE DEV, V14, P1027
[52]   PROTEIN MODULES AND SIGNALING NETWORKS [J].
PAWSON, T .
NATURE, 1995, 373 (6515) :573-580
[53]   Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition [J].
Poy, F ;
Yaffe, MB ;
Sayos, J ;
Saxena, K ;
Morra, M ;
Sumegi, J ;
Cantley, LC ;
Terhorst, C ;
Eck, MJ .
MOLECULAR CELL, 1999, 4 (04) :555-561
[54]  
Raitano A. B., 1997, BIOCHIM BIOPHYS ACTA, V1333, P201, DOI DOI 10.1016/S0304-419X(97)00023-1
[55]   The role of phosphoinositide 3-kinase lipid products in cell function [J].
Rameh, LE ;
Cantley, LC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (13) :8347-8350
[56]   IDENTIFICATION OF A 10-AMINO ACID PROLINE-RICH SH3 BINDING-SITE [J].
REN, RB ;
MAYER, BJ ;
CICCHETTI, P ;
BALTIMORE, D .
SCIENCE, 1993, 259 (5098) :1157-1161
[57]   Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway [J].
Rohatgi, R ;
Nollau, P ;
Ho, HYH ;
Kirschner, MW ;
Mayer, BJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (28) :26448-26452
[58]   THE SH2 AND SH3 DOMAINS OF MAMMALIAN GRB2 COUPLE THE EGF RECEPTOR TO THE RAS ACTIVATOR MSOS1 [J].
ROZAKISADCOCK, M ;
FERNLEY, R ;
WADE, J ;
PAWSON, T ;
BOWTELL, D .
NATURE, 1993, 363 (6424) :83-85
[59]   A NONCATALYTIC DOMAIN CONSERVED AMONG CYTOPLASMIC PROTEIN-TYROSINE KINASES MODIFIES THE KINASE FUNCTION AND TRANSFORMING ACTIVITY OF FUJINAMI SARCOMA-VIRUS P130GAG-FPS [J].
SADOWSKI, I ;
STONE, JC ;
PAWSON, T .
MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (12) :4396-4408
[60]   Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase [J].
Salim, K ;
Bottomley, MJ ;
Querfurth, E ;
Zvelebil, MJ ;
Gout, I ;
Scaife, R ;
Margolis, RL ;
Gigg, R ;
Smith, CIE ;
Driscoll, PC ;
Waterfield, MD ;
Panayotou, G .
EMBO JOURNAL, 1996, 15 (22) :6241-6250